{"id":"W4245330943","doi":"10.21203/rs.3.rs-18810/v1","title":"Genetic Determinants of Obesity Heterogeneity in Type II Diabetes","year":2020,"lang":"en","type":"preprint","venue":"Research Square","topic":"Nutrition, Genetics, and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"","keywords":"Insulin resistance; Endocrinology; Internal medicine; Obesity; GLUT4; Medicine; Type 2 diabetes; Diabetes mellitus; Insulin; PI3K/AKT/mTOR pathway; IRS1; PTEN; Insulin receptor; Protein kinase B; Pathogenesis; Biology; Signal transduction; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003993347,0.0003409419,0.0002396368,0.00085071,0.000334548,0.0005305482,0.0002221417,0.0003519615,0.004069651],"category_scores_gemma":[0.0009892196,0.00020429,0.0003678423,0.0007362882,0.0002490829,0.0001579949,0.0002622923,0.0004978843,0.0001815477],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000124118,"about_ca_system_score_gemma":0.0001308166,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000956232,"about_ca_topic_score_gemma":0.0008360999,"domain_scores_codex":[0.9997264,0.00008239624,0.00002513257,0.00008025476,0.00005041947,0.00003538688],"domain_scores_gemma":[0.9993252,0.0002285509,0.0002488669,0.00004714106,0.00003973065,0.000110471],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008027116,0.0001092947,0.9839224,0.00004178763,0.0003068341,0.0009905169,0.0001199577,0.00009762485,0.009919121,0.0002000507,0.000150736,0.003339043],"study_design_scores_gemma":[0.000009453883,0.00007983232,0.9973877,0.00001624115,0.00009398727,0.001238233,0.0001083588,0.0002281067,0.0004354111,0.0001718386,0.0002265364,0.000004377244],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982577,0.0005428361,0.0003706242,0.00006873694,0.00001284827,0.00001002858,0.0001508362,0.000006273763,0.0005801279],"genre_scores_gemma":[0.9992,0.0001579533,0.0002521235,0.00001701648,0.00001317472,0.000006896609,0.0001288238,0.000004617685,0.0002192761],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004069651,"threshold_uncertainty_score":0.01361436,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05140915435671849,"score_gpt":0.3735820389106826,"score_spread":0.3221728845539641,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}