{"id":"W4245423832","doi":"10.3410/f.734083403.793555176","title":"Faculty Opinions recommendation of LUBAC prevents lethal dermatitis by inhibiting cell death induced by TNF, TRAIL and CD95L.","year":2019,"lang":"en","type":"dataset","venue":"Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Health and Medical Research Council; University of Toronto; National Heart and Lung Institute; Wellcome Trust; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Genentech; Imperial College London; National Science Foundation","keywords":"RIPK1; Necroptosis; Apoptosis; Programmed cell death; Tumor necrosis factor alpha; Inflammation; Receptor; Cancer research; Medicine; Fas ligand; Immunology; Cell biology; Biology; Internal medicine; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000745583,0.001526434,0.001057189,0.00325749,0.0005686279,0.00189502,0.00145475,0.001116301,0.07078354],"category_scores_gemma":[0.004621731,0.0002998064,0.001249789,0.004280997,0.0002538752,0.0009744058,0.001162608,0.00104908,0.04212526],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001288154,"about_ca_system_score_gemma":0.002168724,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01575015,"about_ca_topic_score_gemma":0.04941495,"domain_scores_codex":[0.9992563,0.000142328,0.0000823582,0.0002546971,0.0001629573,0.0001013728],"domain_scores_gemma":[0.9982892,0.0005822526,0.0002725182,0.0002299184,0.000356941,0.000269221],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002925927,0.00004459313,0.004393728,0.00373923,0.0002241942,0.00006467326,0.00005262258,0.0005761322,0.0008581942,0.0005786514,0.9761835,0.01299194],"study_design_scores_gemma":[0.0004871351,0.00004981058,0.01128061,0.0005496831,0.0001532148,0.00008633239,0.00007982796,0.0009229608,0.00143639,0.0008664537,0.9840505,0.00003726359],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"dataset","genre_gemma":"dataset","genre_scores_codex":[0.0008595214,0.00045139,0.00006996301,0.0002315744,0.00004368597,0.00001926482,0.9959012,0.0005872662,0.001836177],"genre_scores_gemma":[0.001872857,0.0002735571,0.0004794225,0.0000732726,0.00001042164,0.00006031224,0.9958263,0.00009283625,0.001310879],"genre_candidate":"dataset","genre_consensus":"dataset","teacher_disagreement_score":0.07078354,"threshold_uncertainty_score":0.2367945,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02850355616381004,"score_gpt":0.3222310727348003,"score_spread":0.2937275165709903,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}