{"id":"W4245473379","doi":"10.1002/ange.201507985","title":"A Convenient Approach to Stereoisomeric Iminocyclitols: Generation of Potent Brain‐Permeable OGA Inhibitors","year":2015,"lang":"en","type":"article","venue":"Angewandte Chemie","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"Biotechnology and Biological Sciences Research Council; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Michael Smith Health Research BC","keywords":"Epimer; Chemistry; Pyrrolidine; Enzyme; Potency; Biochemistry; In vitro; Stereochemistry; Computational biology; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001815526,0.0004871473,0.0002013537,0.0002166155,0.0001262974,0.0002173365,0.000292055,0.0002560609,0.001563411],"category_scores_gemma":[0.000162488,0.0001275336,0.0001544754,0.0001778816,0.000162148,0.0003276605,0.0002433507,0.0007115151,0.0005358079],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002261108,"about_ca_system_score_gemma":0.0002817916,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002935197,"about_ca_topic_score_gemma":0.0005188272,"domain_scores_codex":[0.9999009,0.00001786402,0.00001043154,0.00002199874,0.00001998587,0.00002870701],"domain_scores_gemma":[0.9999353,0.000008942267,0.00002075399,0.000009919231,0.00001074358,0.00001445335],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001213672,0.00009148817,0.00005352437,0.0001427375,0.000008873078,0.0001657016,0.00004979798,0.0004600444,0.9826087,0.002600915,0.0004301546,0.01326669],"study_design_scores_gemma":[0.00003926711,0.0006550477,0.0001840924,0.000006565248,0.000008455606,0.0002218341,0.00001120938,0.000432128,0.9869702,0.0001811518,0.01127862,0.00001143038],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8465585,0.01120625,0.1039234,0.001007464,0.0004061223,0.0007685896,0.002095023,0.0007453907,0.03328929],"genre_scores_gemma":[0.9651239,0.005575038,0.0236352,0.0001801361,0.00004653642,0.0001650261,0.0004449733,0.00006370772,0.00476543],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001563411,"threshold_uncertainty_score":0.005230069,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07456224094666485,"score_gpt":0.2957963214497188,"score_spread":0.2212340805030539,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}