{"id":"W4245477661","doi":"10.22215/etd/2014-10442","title":"Characterization of the active site of Methionine γ-Lyase from Trichomonas vaginalis","year":2014,"lang":"en","type":"dissertation","venue":"","topic":"Cancer Research and Treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University","funders":"","keywords":"Prodrug; Trichomonas vaginalis; Active site; Lyase; Biochemistry; Methionine; Enzyme; Cysteine; Chemistry; Biology; Homocysteine; Tinidazole; Microbiology; Antibiotics; Amino acid; Metronidazole","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001401551,0.0002150901,0.0001214915,0.0002414839,0.0001188171,0.0002549396,0.0002475806,0.000228373,0.001051858],"category_scores_gemma":[0.0002984588,0.00008926715,0.0002126751,0.0002193628,0.0001113951,0.000151147,0.00008751977,0.0003173823,0.0005723613],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002585945,"about_ca_system_score_gemma":0.000372398,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002471694,"about_ca_topic_score_gemma":0.001834657,"domain_scores_codex":[0.9999447,0.000006629819,0.00000466325,0.00001071295,0.00002062212,0.00001273581],"domain_scores_gemma":[0.9999379,0.00001718383,0.0000105911,0.000005151689,0.00001627097,0.00001294751],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001312072,0.0000363706,0.000700366,0.00007192435,0.000006167816,0.0001410376,0.0000490575,0.00010951,0.9916565,0.0001585669,0.00009460087,0.006844589],"study_design_scores_gemma":[0.00002265521,0.0003001818,0.01839035,0.00002886392,0.00002181204,0.0009248782,0.0001830854,0.0006391261,0.963555,0.0001974399,0.0157257,0.00001079377],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9824322,0.004697396,0.005616702,0.0004050869,0.00003575,0.00006650828,0.001214198,0.00002678264,0.005505518],"genre_scores_gemma":[0.9677789,0.005468586,0.006588214,0.0001282132,0.00002438237,0.00004017692,0.007708255,0.00003585056,0.01222754],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002471694,"threshold_uncertainty_score":0.004914582,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006883782697500493,"score_gpt":0.2778250837176099,"score_spread":0.2709413010201094,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}