{"id":"W4245477772","doi":"10.1200/jco.2012.30.27_suppl.102","title":"Effects of everolimus (EVE) on disease progression in bone and bone markers (BMs) in patients (pts) with bone metastases (mets).","year":2012,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Sunnybrook Health Science Centre","funders":"","keywords":"Medicine; Internal medicine; Bone remodeling; N-terminal telopeptide; Bone resorption; Everolimus; Clinical endpoint; Bisphosphonate; Denosumab; Bone mineral; Exemestane; Osteoclast; Osteoporosis; Endocrinology; Oncology; Breast cancer; Urology; Cancer; Clinical trial; Aromatase; Osteocalcin; Alkaline phosphatase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006545357,0.0003859795,0.001002755,0.0002148841,0.0001289167,0.0003349517,0.0002477926,0.0004020444,0.00205854],"category_scores_gemma":[0.0006698683,0.0001930699,0.0008428684,0.0002535143,0.0002144356,0.0002745492,0.0002102051,0.0009334556,0.0002385358],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002858462,"about_ca_system_score_gemma":0.0003367731,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004055261,"about_ca_topic_score_gemma":0.001984044,"domain_scores_codex":[0.9998079,0.00009555865,0.00001712111,0.00002520878,0.0000243451,0.00002992694],"domain_scores_gemma":[0.99971,0.00008581737,0.00008505004,0.00001279427,0.00001205151,0.00009417342],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.7382607,0.0118384,0.02668056,0.00168723,0.002535581,0.0002533997,0.0001647412,0.00124708,0.02534135,0.0002025659,0.002039156,0.1897493],"study_design_scores_gemma":[0.2380618,0.5275127,0.2175447,0.0002250807,0.002592976,0.0008199918,0.0001646259,0.001357027,0.004455047,0.0002668088,0.006963614,0.00003559294],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9897544,0.008240134,0.00008021062,0.0001902084,0.00004207462,0.0001608868,0.00036341,0.00001635015,0.001152301],"genre_scores_gemma":[0.9943424,0.00340862,0.0003157007,0.0002840143,0.00006131236,0.0001833048,0.0005684482,0.000003690947,0.0008325148],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00205854,"threshold_uncertainty_score":0.006886482,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03116887656501204,"score_gpt":0.4123450738408524,"score_spread":0.3811761972758404,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}