{"id":"W4245587174","doi":"10.1007/978-3-319-67199-4_101763","title":"DREAM (Downstream Regulatory Element Antagonist Modulator)","year":2017,"lang":"en","type":"book-chapter","venue":"","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Downstream (manufacturing); Antagonist; Chemistry; Engineering; Receptor; Operations management","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002154304,0.0005661721,0.0004302949,0.0004601861,0.0002534152,0.0008471258,0.0007906318,0.0005121134,0.02159133],"category_scores_gemma":[0.0001834666,0.0002121041,0.0002771959,0.0004240705,0.0002803334,0.0008602594,0.0007498954,0.0014648,0.01852184],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003650008,"about_ca_system_score_gemma":0.0002703907,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002020429,"about_ca_topic_score_gemma":0.0004892344,"domain_scores_codex":[0.999916,0.000007381439,0.000004105186,0.000023662,0.00003928357,0.000009581434],"domain_scores_gemma":[0.9999725,0.000009105715,0.000003240185,0.000003756867,0.000005899547,0.000005628281],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002094053,0.00006087635,0.0001172727,0.001002773,0.00001956144,0.0002559421,0.00009443021,0.0006956469,0.06673089,0.08234819,0.128849,0.7196161],"study_design_scores_gemma":[0.000008169538,0.00002857978,0.0001075527,0.00007504519,0.000009458573,0.0003857133,0.00001847387,0.0001710253,0.01031041,0.006480372,0.9823968,0.000008425251],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"other","genre_gemma":"empirical","genre_scores_codex":[0.008328397,0.3266636,0.06846651,0.005266772,0.008378673,0.0001347344,0.002931907,0.002943705,0.5768858],"genre_scores_gemma":[0.02609001,0.1146791,0.02828599,0.00235532,0.001059736,0.0001783507,0.002044072,0.0003830885,0.8249243],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.02159133,"threshold_uncertainty_score":0.07223022,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01240208545144513,"score_gpt":0.2348991100045564,"score_spread":0.2224970245531113,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}