{"id":"W4245594967","doi":"10.3410/f.733081327.793546199","title":"Faculty Opinions recommendation of Mfn2 ubiquitination by PINK1/parkin gates the p97-dependent release of ER from mitochondria to drive mitophagy.","year":2018,"lang":"en","type":"dataset","venue":"Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; Medical Research Council; Genome Canada; McGill University","keywords":"Mitophagy; MFN2; Parkin; PINK1; Mitochondrion; VDAC1; Cell biology; Ubiquitin ligase; Ubiquitin; Autophagy; FIS1; Biology; Chemistry; mitochondrial fusion; Biochemistry; Bacterial outer membrane; Apoptosis; Mitochondrial DNA; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008512188,0.001112235,0.0009062734,0.003709263,0.000543212,0.001558291,0.001418478,0.0007983217,0.03720149],"category_scores_gemma":[0.005323162,0.0002560853,0.0008032156,0.005922652,0.000248962,0.0007878682,0.001170004,0.0009074377,0.0312161],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001331556,"about_ca_system_score_gemma":0.001887091,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0131745,"about_ca_topic_score_gemma":0.03535329,"domain_scores_codex":[0.9990858,0.0001240397,0.0001140015,0.0002729329,0.0002786278,0.0001246471],"domain_scores_gemma":[0.9977849,0.0006488701,0.0005010949,0.0003300746,0.0004733799,0.0002616614],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003226293,0.00003926979,0.01974634,0.00347393,0.0002358328,0.0001488092,0.0001054528,0.000831445,0.001035172,0.001114461,0.9551361,0.01781054],"study_design_scores_gemma":[0.0001534394,0.00002156519,0.02419597,0.0003472412,0.0001172686,0.0001446883,0.00009986356,0.0006823944,0.001390321,0.000771295,0.9720524,0.00002357482],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"dataset","genre_gemma":"dataset","genre_scores_codex":[0.001708661,0.000396831,0.0001056245,0.0001846192,0.00002960476,0.0000108698,0.995218,0.0003326266,0.002013213],"genre_scores_gemma":[0.003552326,0.0002651904,0.0003693688,0.00004431659,0.00001292474,0.00003769,0.9941837,0.00005420939,0.001480234],"genre_candidate":"dataset","genre_consensus":"dataset","teacher_disagreement_score":0.03720149,"threshold_uncertainty_score":0.1244514,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01627170288612758,"score_gpt":0.3196474925034956,"score_spread":0.303375789617368,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}