{"id":"W4245855405","doi":"10.1158/1538-7445.sabcs18-ct166","title":"Abstract CT166: A Phase I/II, open-label, two part study of GSK3359609 in combination with tremelimumab in participants with selected, advanced solid tumors","year":2019,"lang":"en","type":"article","venue":"Clinical Trials","topic":"Cancer Research and Treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Princess Margaret Cancer Centre","funders":"","keywords":"Tremelimumab; Open label; Medicine; Solid tumor; Computer science; Oncology; Internal medicine; Clinical trial; Cancer; Immunotherapy; Ipilimumab","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00288557,0.0001809039,0.0009125844,0.00007342923,0.00003196671,0.00002793534,0.000265134,0.00008619064,0.00005292224],"category_scores_gemma":[0.001227545,0.0001282938,0.00004101224,0.0003261152,0.00007015524,0.00001872684,0.0001241751,0.0001866468,0.000007801968],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003427241,"about_ca_system_score_gemma":0.0003869656,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003223201,"about_ca_topic_score_gemma":0.00509845,"domain_scores_codex":[0.9969153,0.0006929662,0.001193759,0.0005601653,0.0002534847,0.0003843587],"domain_scores_gemma":[0.998542,0.0002991154,0.0004416317,0.0004294263,0.000145738,0.0001420937],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.1393622,0.1093582,0.5485077,0.00008838749,0.001220335,0.0002458977,0.0004042224,0.000605774,0.1181357,0.00001986739,0.0003672713,0.08168446],"study_design_scores_gemma":[0.6172574,0.1543284,0.154724,0.0006017422,0.0001598117,0.000005927473,0.000760349,0.0001967265,0.07045456,0.0001211511,0.000718551,0.0006714304],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967607,0.0001100436,0.000003527998,0.00004708333,0.00005743271,0.002789822,0.00003105327,0.000005370307,0.0001949611],"genre_scores_gemma":[0.9992463,0.0000956591,0.00007513903,0.00003409162,0.00004462508,0.0002822186,0.00009009174,0.00002139908,0.0001104562],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4778951,"threshold_uncertainty_score":0.5231668,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2348020594165081,"score_gpt":0.5398216789347781,"score_spread":0.30501961951827,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}