{"id":"W4245855405","doi":"10.1158/1538-7445.sabcs18-ct166","title":"Abstract CT166: A Phase I/II, open-label, two part study of GSK3359609 in combination with tremelimumab in participants with selected, advanced solid tumors","year":2019,"lang":"en","type":"article","venue":"Clinical Trials","topic":"Cancer Research and Treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa; Princess Margaret Cancer Centre","funders":"","keywords":"Tremelimumab; Open label; Medicine; Solid tumor; Computer science; Oncology; Internal medicine; Clinical trial; Cancer; Immunotherapy; Ipilimumab","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002574102,0.003272138,0.002888917,0.000753164,0.0009370378,0.0009761168,0.001407821,0.00243525,0.01048127],"category_scores_gemma":[0.001179692,0.001083374,0.001736582,0.0005526,0.00136415,0.001592383,0.0005692526,0.003933268,0.002966616],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001037536,"about_ca_system_score_gemma":0.002559676,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001051141,"about_ca_topic_score_gemma":0.002627426,"domain_scores_codex":[0.9992427,0.000358498,0.00005232474,0.000129028,0.00008751378,0.0001300351],"domain_scores_gemma":[0.9987142,0.0001350729,0.0002491879,0.00008187626,0.0001010357,0.0007185788],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.771119,0.1564682,0.003509896,0.001215309,0.0006642868,0.00032874,0.0002407499,0.0007862422,0.03322539,0.0001475912,0.002972312,0.02932226],"study_design_scores_gemma":[0.4258714,0.5675208,0.003670743,0.00001786826,0.000176668,0.0001371133,0.00003809681,0.0002092387,0.001226581,0.00007296414,0.0010399,0.00001866827],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.979427,0.001326355,0.0009157989,0.0006633662,0.0002420856,0.0127379,0.002652889,0.0002107537,0.001823931],"genre_scores_gemma":[0.9569065,0.002193222,0.00414273,0.002426876,0.0006214866,0.01890185,0.004469593,0.00007625347,0.01026142],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01048127,"threshold_uncertainty_score":0.03506333,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2348020594165081,"score_gpt":0.5398216789347781,"score_spread":0.30501961951827,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}