{"id":"W4246032552","doi":"10.1542/peds.2007-1131","title":"Do We Need to Incorporate Pharmacogenetics in Randomized, Controlled Trials of Frequently Used Medicines?: In Reply","year":2007,"lang":"en","type":"article","venue":"PEDIATRICS","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa","funders":"","keywords":"Medicine; Pharmacogenetics; Randomized controlled trial; Intensive care medicine; Medical physics; Internal medicine; Genetics; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.05062611,0.001224038,0.004650201,0.001648164,0.002255188,0.00378222,0.00473607,0.03739983,0.006568915],"category_scores_gemma":[0.1789649,0.001562935,0.002463643,0.002421904,0.004914604,0.006182967,0.002131988,0.0444516,0.003297945],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003239209,"about_ca_system_score_gemma":0.005576955,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00420232,"about_ca_topic_score_gemma":0.008922749,"domain_scores_codex":[0.981306,0.009015362,0.005072423,0.001610415,0.002395984,0.0005998551],"domain_scores_gemma":[0.7401915,0.2173607,0.009431727,0.005021835,0.02275126,0.005242867],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0006322563,0.00007487083,0.001865453,0.000778232,0.0004267006,0.0003297545,0.0002020838,0.0001637664,0.0001797009,0.002000357,0.9786245,0.01472236],"study_design_scores_gemma":[0.004520405,0.0006038735,0.009457225,0.002306355,0.001817696,0.001372522,0.001245226,0.001717412,0.0009811639,0.01691272,0.9585968,0.0004686792],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.0004292975,0.004020203,0.0006594827,0.9428434,0.0511284,0.00006962388,0.0003665453,0.00006271921,0.0004202739],"genre_scores_gemma":[0.002272255,0.001514944,0.00171695,0.9565835,0.03689848,0.0001599606,0.00006733088,0.00002887437,0.0007577152],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.05062611,"threshold_uncertainty_score":0.2677397,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1251734299071902,"score_gpt":0.458287511734029,"score_spread":0.3331140818268389,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}