{"id":"W4246035151","doi":"10.1002/ange.201510650","title":"Expanding the Landscape of Diterpene Structural Diversity through Stereochemically Controlled Combinatorial Biosynthesis","year":2016,"lang":"en","type":"article","venue":"Angewandte Chemie","topic":"Plant biochemistry and biosynthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; University of California, Davis; Danmarks Tekniske Universitet; Novo Nordisk; Directorate for Biological Sciences; Novo Nordisk Fonden; European Research Council; Iowa State University","keywords":"Diterpene; Biosynthesis; Enantiomer; Chemistry; Stereochemistry; Diastereomer; Stereoselectivity; Modularity (biology); Computational biology; Enzyme; Biology; Biochemistry; Evolutionary biology; Catalysis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002634819,0.0004339977,0.0002332168,0.0004649668,0.0001632487,0.0005979922,0.0002902106,0.0001823395,0.00155646],"category_scores_gemma":[0.0002526695,0.0001948958,0.0002411682,0.0003540907,0.0002811058,0.0003256267,0.0004660124,0.000451219,0.0005092436],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004220961,"about_ca_system_score_gemma":0.0002487165,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002518453,"about_ca_topic_score_gemma":0.0006854277,"domain_scores_codex":[0.9998657,0.00001997009,0.00001312817,0.00003587114,0.00003116137,0.00003427862],"domain_scores_gemma":[0.9998617,0.0000261732,0.00002599053,0.00003525316,0.0000189641,0.00003193519],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009778349,0.00004850703,0.000397068,0.00005672221,0.00001237681,0.0001067991,0.0000292446,0.001853253,0.9861662,0.002997681,0.0001692863,0.008065116],"study_design_scores_gemma":[0.00002585496,0.0001799952,0.0005512211,0.000007401411,0.00002403213,0.0001212821,0.00002390668,0.004880343,0.9857526,0.0006351874,0.007783177,0.00001495908],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9590081,0.001217915,0.02741316,0.0002450141,0.00006056584,0.0001299968,0.0006265369,0.0006813169,0.01061733],"genre_scores_gemma":[0.9819677,0.0008247649,0.01504495,0.00005334981,0.000009179322,0.00004475088,0.0002831582,0.00006740442,0.001704592],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00155646,"threshold_uncertainty_score":0.005206883,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01211087846611126,"score_gpt":0.2274646659007058,"score_spread":0.2153537874345945,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}