{"id":"W4246099038","doi":"10.1002/ange.202000025","title":"In Vitro Selection of a DNA Aptamer Targeting Degraded Protein Fragments for Biosensing","year":2020,"lang":"en","type":"article","venue":"Angewandte Chemie","topic":"Bacteriophages and microbial interactions","field":"Environmental Science","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada; National Natural Science Foundation of China","keywords":"Aptamer; Toxin; Systematic evolution of ligands by exponential enrichment; Clostridium difficile; Recombinant DNA; DNA; Clostridium difficile toxin B; Clostridium difficile toxin A; Chemistry; Molecular biology; Biology; Microbiology; Computational biology; Biochemistry; Gene; Antibiotics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004035292,0.0005267436,0.0002918068,0.0002677696,0.0001238306,0.0003419782,0.0003166252,0.0005391106,0.0006462024],"category_scores_gemma":[0.0004954113,0.0002297664,0.0002338489,0.0002309286,0.0002453681,0.0001823602,0.0002644453,0.000494266,0.0005141498],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003029893,"about_ca_system_score_gemma":0.0001791224,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000368612,"about_ca_topic_score_gemma":0.0004753808,"domain_scores_codex":[0.9996006,0.00009578891,0.00003221705,0.0001062384,0.0001120264,0.00005324312],"domain_scores_gemma":[0.9996403,0.000133809,0.00007842098,0.00003388982,0.00005332507,0.00006029277],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000007118758,0.000006982694,0.00001919859,0.000007288625,0.000001142752,0.000008547808,0.000005647482,0.00005052196,0.9995751,0.00001686226,0.000009339637,0.0002922213],"study_design_scores_gemma":[0.000002675113,0.00005303575,0.0001004492,0.00000135734,0.000002142379,0.00002780899,0.000003480484,0.0006479936,0.9986975,0.000008207811,0.0004535347,0.000002012433],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8976747,0.001201048,0.09794352,0.0001942003,0.0001352872,0.0001967553,0.0002963805,0.0003340652,0.002024006],"genre_scores_gemma":[0.9217647,0.0005710671,0.07085682,0.0001846502,0.000025012,0.0001675572,0.0007145916,0.0001020885,0.00561349],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006462024,"threshold_uncertainty_score":0.002198339,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01733257146961546,"score_gpt":0.2390699640764209,"score_spread":0.2217373926068055,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}