{"id":"W4246222172","doi":"10.21203/rs.2.13361/v1","title":"A three-arm, multicenter, open-label randomized controlled trial of hydroxychloroquine and low-dose prednisone on recurrent spontaneous abortion with undifferentiated connective tissue diseases: Protocol for the immunosuppressant regimens for Living FEtuses (ILIFE) Trial","year":2019,"lang":"en","type":"preprint","venue":"Research Square","topic":"Reproductive System and Pregnancy","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Hamilton Health Sciences; Impact; McMaster University Medical Centre","funders":"","keywords":"Hydroxychloroquine; Medicine; Prednisone; Abortion; Open label; Connective tissue; Randomized controlled trial; Internal medicine; Pregnancy; Pathology; Biology; Coronavirus disease 2019 (COVID-19)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.005953575,0.000719887,0.003584185,0.0003481697,0.0005523718,0.000242735,0.001000944,0.0005948783,0.0001263288],"category_scores_gemma":[0.007574457,0.0004026394,0.0004893354,0.0001647235,0.0006935753,0.0001247421,0.0009419873,0.0009543588,0.000009384763],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001960792,"about_ca_system_score_gemma":0.000819156,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004326947,"about_ca_topic_score_gemma":0.0001564137,"domain_scores_codex":[0.9907233,0.004867667,0.001585246,0.001567253,0.0004017589,0.0008548499],"domain_scores_gemma":[0.977011,0.01810268,0.001560071,0.001575539,0.001672819,0.00007790425],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.979497,0.006635463,0.00002639019,0.003308363,0.004290693,0.000007455906,0.001118718,0.00003919881,0.003513154,0.0002814949,0.0004141087,0.0008680316],"study_design_scores_gemma":[0.9590985,0.02527937,0.0001132767,0.01008605,0.0008185107,0.00001597114,0.0003326671,0.0005249566,0.002528347,0.0004524916,0.0003122744,0.0004376187],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.1510515,0.004132463,0.001310651,0.0002138302,0.001730958,0.8401235,0.00131492,0.00005977879,0.00006237702],"genre_scores_gemma":[0.4955205,0.0001266304,0.00003334273,0.000003576485,0.0001923989,0.5032238,0.0002943009,0.00006241733,0.0005430607],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.344469,"threshold_uncertainty_score":0.9998425,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0647682674107467,"score_gpt":0.4044670144724262,"score_spread":0.3396987470616795,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}