{"id":"W4246263947","doi":"10.3410/f.736084882.793562821","title":"Faculty Opinions recommendation of Small-Molecule Modulation of TDP-43 Recruitment to Stress Granules Prevents Persistent TDP-43 Accumulation in ALS/FTD.","year":2019,"lang":"en","type":"dataset","venue":"Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Amyotrophic lateral sclerosis; Frontotemporal dementia; Stress granule; Small molecule; Cell biology; RNA; Neuroscience; Frontotemporal lobar degeneration; Chemistry; Dementia; Biology; Medicine; Biochemistry; Internal medicine; Gene; Messenger RNA; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001845918,0.0006688859,0.0005746857,0.001321314,0.001938011,0.003326521,0.001039866,0.003285827,0.5034791],"category_scores_gemma":[0.004554371,0.0004251972,0.0007691892,0.001615611,0.0005454443,0.001266178,0.00106627,0.002211758,0.2230679],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002752434,"about_ca_system_score_gemma":0.00737925,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008775703,"about_ca_topic_score_gemma":0.02517326,"domain_scores_codex":[0.9985468,0.00009590884,0.00008197199,0.0001674051,0.0009131852,0.0001945683],"domain_scores_gemma":[0.9940289,0.0002894628,0.0003898057,0.0002615959,0.003147691,0.001882572],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001982047,0.0001541925,0.0006685018,0.0004769465,0.00002393516,0.0002258807,0.00006947672,0.0001231082,0.01489279,0.001589964,0.8388787,0.1426983],"study_design_scores_gemma":[0.00004833063,0.00008050839,0.001158758,0.0001020077,0.00001528806,0.00006293742,0.00008497335,0.0001152338,0.002846593,0.0005205849,0.9949505,0.00001417352],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"other","genre_gemma":"commentary","genre_scores_codex":[0.006962152,0.00821865,0.006102915,0.09028994,0.04209277,0.0013447,0.01623508,0.00278234,0.8259714],"genre_scores_gemma":[0.01433642,0.007532557,0.005717017,0.01220183,0.007996448,0.0003061865,0.005793823,0.0005257933,0.9455899],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.5034791,"threshold_uncertainty_score":0.7082268,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1599293955739967,"score_gpt":0.4326762897715681,"score_spread":0.2727468941975714,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}