{"id":"W4246278554","doi":"10.1158/1538-7445.sabcs18-ct012","title":"Abstract CT012: Open-label, multicenter, Phase Ib study to assess safety, tolerability and efficacy of adavosertib monotherapy in patients with advanced solid tumors: Expansion cohorts","year":2019,"lang":"en","type":"article","venue":"Clinical Trials","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Alberta","funders":"","keywords":"Tolerability; Medicine; Oncology; Open label; Internal medicine; Adverse effect","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00289605,0.0002057437,0.001773298,0.00007129188,0.00003755917,0.00002997396,0.0001382339,0.00007002651,0.0001184283],"category_scores_gemma":[0.001957076,0.0001358171,0.00006955331,0.0001649512,0.00005102198,0.0001839511,0.00008058665,0.0001712926,0.000009357961],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008848582,"about_ca_system_score_gemma":0.0001943544,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001085229,"about_ca_topic_score_gemma":0.00005968444,"domain_scores_codex":[0.9963533,0.0005241931,0.002017784,0.0005982749,0.0003004611,0.0002059931],"domain_scores_gemma":[0.996226,0.002224354,0.0005426595,0.0005625406,0.0002014734,0.0002429969],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.06348516,0.05010381,0.7857336,0.00004903958,0.000320876,0.00001061595,0.0005370862,0.00002953592,0.0005589094,0.000002338167,0.00002365223,0.09914535],"study_design_scores_gemma":[0.175908,0.01688718,0.8058571,0.0004552022,0.0001873035,1.727603e-7,0.0002139899,0.00001586599,0.0002619055,0.00000877116,0.00008272396,0.0001217267],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885508,0.00005554431,0.00001779678,0.00016638,0.0002661321,0.01076697,0.00006081628,0.00001736278,0.00009823687],"genre_scores_gemma":[0.9986068,0.00004354857,0.0008225821,0.0002601068,0.00004576341,0.0001006692,0.00005323959,0.00002596526,0.00004133919],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1124229,"threshold_uncertainty_score":0.5538462,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1736007637037636,"score_gpt":0.544113882138634,"score_spread":0.3705131184348704,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}