{"id":"W4246278554","doi":"10.1158/1538-7445.sabcs18-ct012","title":"Abstract CT012: Open-label, multicenter, Phase Ib study to assess safety, tolerability and efficacy of adavosertib monotherapy in patients with advanced solid tumors: Expansion cohorts","year":2019,"lang":"en","type":"article","venue":"Clinical Trials","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Alberta","funders":"","keywords":"Tolerability; Medicine; Oncology; Open label; Internal medicine; Adverse effect","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002231473,0.00172028,0.001738097,0.0005310542,0.0006686992,0.001169323,0.001147723,0.001020376,0.0081076],"category_scores_gemma":[0.001288831,0.0004975209,0.001260274,0.0007695818,0.001169703,0.001083657,0.0005203758,0.002945567,0.001936476],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001648649,"about_ca_system_score_gemma":0.003283767,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00197447,"about_ca_topic_score_gemma":0.004516187,"domain_scores_codex":[0.9993279,0.000297925,0.00004254849,0.0001228339,0.00007948991,0.0001293763],"domain_scores_gemma":[0.9988907,0.00009484103,0.0001991898,0.000101331,0.00010308,0.0006108125],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7377157,0.07321607,0.02263389,0.0006489251,0.001012384,0.000441053,0.0003150023,0.002200371,0.08008796,0.0004624376,0.01258302,0.06868319],"study_design_scores_gemma":[0.4121659,0.5383623,0.03232795,0.00006390862,0.0005624546,0.0007899375,0.0001594781,0.001758091,0.0063489,0.0003512984,0.00704976,0.00006004054],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9813421,0.001425201,0.001128767,0.0003736822,0.000134629,0.005808969,0.006062044,0.0002439232,0.003480573],"genre_scores_gemma":[0.9714661,0.0008424011,0.003128694,0.001074212,0.0002009769,0.005314728,0.01423653,0.00006501576,0.003671396],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0081076,"threshold_uncertainty_score":0.02712262,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1736007637037636,"score_gpt":0.544113882138634,"score_spread":0.3705131184348704,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}