{"id":"W4246281493","doi":"10.22541/au.161576770.06456387/v1","title":"Screening for patients with Gaucher’s disease using routine pathology results: PATHFINDER (ferritin, alkaline phosphatase, platelets) study","year":2021,"lang":"en","type":"preprint","venue":"","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Thomas Hospital","funders":"","keywords":"Ferritin; Glucocerebrosidase; Medicine; Alkaline phosphatase; Biomarker; Internal medicine; Pathology; Phenotype; Gastroenterology; Disease; Biology; Enzyme; Genetics; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007005068,0.0002812575,0.0003274122,0.001255426,0.0003644585,0.0005224947,0.0003005037,0.0004171601,0.001037409],"category_scores_gemma":[0.001925201,0.0001894316,0.000308145,0.0008628746,0.0001889053,0.0003605189,0.0003361829,0.0002923643,0.000359202],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002146649,"about_ca_system_score_gemma":0.0002397838,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001684689,"about_ca_topic_score_gemma":0.001385398,"domain_scores_codex":[0.9995857,0.0001053632,0.00006855311,0.0001121811,0.00007884675,0.0000493617],"domain_scores_gemma":[0.9992301,0.0002170699,0.0002604655,0.00004952863,0.0001182422,0.0001244606],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001755598,0.00004488019,0.9965574,0.00001256729,0.00001539754,0.0005953331,0.00007026811,0.00001821286,0.0006085227,0.00001186385,0.0000977021,0.001792384],"study_design_scores_gemma":[0.00004658,0.0006817348,0.9902974,0.00001956495,0.00006323864,0.006619975,0.0002597915,0.000388945,0.0008148242,0.00003955399,0.0007607139,0.000007692443],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991149,0.0001658107,0.0001159195,0.00002707371,0.000003111543,0.00002034581,0.0001834433,0.000006134572,0.0003632332],"genre_scores_gemma":[0.9990743,0.00008301847,0.0003155054,0.00003675038,0.000006554678,0.00001354149,0.0003255411,0.000001568011,0.0001432241],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001684689,"threshold_uncertainty_score":0.003704667,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06070704165287465,"score_gpt":0.3431710765544944,"score_spread":0.2824640349016198,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}