{"id":"W4246294147","doi":"10.1002/9781119951438.eibc0507","title":"Calpain","year":2004,"lang":"en","type":"other","venue":"Encyclopedia of Inorganic and Bioinorganic Chemistry","topic":"Calpain Protease Function and Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Calpain; Proteases; Protease; Papain; Active site; Gene isoform; Chemistry; Enzyme; Biochemistry; Cysteine protease; Catalytic triad; Binding site; Intracellular; Cell biology; Biophysics; Stereochemistry; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00009176115,0.0003386421,0.0003097127,0.00005001559,0.0000380426,0.000009985458,0.0001760837,0.0007629617,0.002442802],"category_scores_gemma":[0.00008489077,0.000319856,0.0001029575,0.0001295165,0.0001903032,0.000001770773,0.0001579408,0.0001726196,0.00002512033],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002750372,"about_ca_system_score_gemma":0.0002834991,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006660626,"about_ca_topic_score_gemma":0.00003320246,"domain_scores_codex":[0.9987705,0.00002210621,0.0003018119,0.0005089238,0.0001782911,0.0002183159],"domain_scores_gemma":[0.9991056,0.000006551503,0.000268171,0.0004441737,0.0000393783,0.0001361308],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003886168,0.000128482,0.0007864998,0.0007688211,0.0001894869,0.000005439414,0.00003727061,5.585384e-7,0.5874488,0.00002737617,0.4082178,0.002350535],"study_design_scores_gemma":[0.0008029666,0.00007450527,0.0002326071,0.0001650697,0.00007333242,0.00005960798,0.00006595969,0.000001206566,0.1590421,0.00004654725,0.8389566,0.0004794415],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"other","genre_gemma":"other","genre_scores_codex":[0.03108678,0.01695191,0.001256374,0.0002897349,0.0007598145,0.0008203744,0.0002721957,0.0002339277,0.9483289],"genre_scores_gemma":[0.0451666,0.008013839,0.0005413672,0.0001426521,0.001698317,0.00001497739,0.0007290628,0.0004707405,0.9432225],"genre_candidate":"other","genre_consensus":"other","teacher_disagreement_score":0.4307388,"threshold_uncertainty_score":0.9999254,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002601178838326199,"score_gpt":0.1907950494325731,"score_spread":0.1881938705942469,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}