{"id":"W4246311868","doi":"10.21203/rs.3.rs-19015/v1","title":"Association of tau accumulation and atrophy in mild cognitive impairment: a longitudinal study","year":2020,"lang":"en","type":"preprint","venue":"Research Square","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; Anhui Polytechnic University; H. Lundbeck A/S; Servier; Eisai; Novartis Pharmaceuticals Corporation; BioClinica; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; F. Hoffmann-La Roche; Biogen; Eli Lilly and Company; Bristol-Myers Squibb; National Institute on Aging; Key Laboratory of Anhui Province for Testing Technology and Energy-saving Devices; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Cognitive impairment; Atrophy; Association (psychology); Cognition; Psychology; Medicine; Neuroscience; Internal medicine; Psychotherapist","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002530471,0.0005762294,0.0005514012,0.001074678,0.001123173,0.001176637,0.000669303,0.001143549,0.001772923],"category_scores_gemma":[0.004594326,0.0008097269,0.0007610883,0.001172974,0.0005511729,0.001222307,0.0007775579,0.001216367,0.0005486393],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004415306,"about_ca_system_score_gemma":0.0007015638,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0136789,"about_ca_topic_score_gemma":0.01131213,"domain_scores_codex":[0.9993698,0.0002361794,0.00004663644,0.0001615252,0.00008734664,0.00009857325],"domain_scores_gemma":[0.9977726,0.0003446426,0.0005823844,0.000391257,0.0003932299,0.0005159064],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002406769,0.0005806754,0.9926843,0.00001506973,0.000400943,0.0002250538,0.000427165,0.00004873734,0.0005895197,0.00004885768,0.0002751291,0.002297779],"study_design_scores_gemma":[0.00004423479,0.0003705021,0.9985563,0.000007118641,0.0001172327,0.0001968581,0.0002203119,0.0001062292,0.00005844256,0.00008021619,0.0002334746,0.000009153382],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987596,0.0003657628,0.00009481728,0.00008155283,0.00001314015,0.000008710075,0.0003884658,0.000005533226,0.0002824004],"genre_scores_gemma":[0.9975853,0.0002553869,0.0001948111,0.0000716854,0.00002987964,0.00001732683,0.0006162939,0.000006159812,0.001223148],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0136789,"threshold_uncertainty_score":0.02719855,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1397953775809316,"score_gpt":0.4715778352642884,"score_spread":0.3317824576833568,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}