{"id":"W4246340264","doi":"10.1002/ange.202012956","title":"Molecularly Imprinted Polymer‐Based Smart Prodrug Delivery System for Specific Targeting, Prolonged Retention, and Tumor Microenvironment‐Triggered Release","year":2020,"lang":"en","type":"article","venue":"Angewandte Chemie","topic":"Analytical chemistry methods development","field":"Chemistry","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Nanjing University; Ministry of Science and Technology of the People's Republic of China; National Natural Science Foundation of China","keywords":"Prodrug; Drug delivery; Chemistry; Tumor microenvironment; Targeted drug delivery; Pharmacology; Cancer research; Medicine; Biochemistry; Tumor cells; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002626684,0.0004236034,0.0004805714,0.00003169522,0.0001629828,0.000082054,0.0002972181,0.0001745945,0.0002794296],"category_scores_gemma":[0.00027032,0.0004320483,0.000214215,0.000161324,0.0001456759,0.00008241831,0.0001443913,0.0003033772,0.00002070603],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002534212,"about_ca_system_score_gemma":0.000101234,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007995852,"about_ca_topic_score_gemma":2.903376e-7,"domain_scores_codex":[0.9975198,0.00003363259,0.0006161751,0.0009534956,0.0003381193,0.0005387701],"domain_scores_gemma":[0.9986194,0.0001180038,0.0002796915,0.0003979012,0.0001163503,0.0004686136],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004231862,0.00006463281,0.0006848112,0.001668702,0.000112384,0.00006899102,0.00009824664,6.193654e-7,0.9953462,0.000007517036,0.001334728,0.0001899369],"study_design_scores_gemma":[0.001756185,0.000031965,0.00004939228,0.0001543601,0.0001346246,0.00001513141,0.0002496052,0.0004422233,0.983709,0.000008538929,0.01297635,0.0004726484],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.952132,0.005803785,0.03395443,0.002895404,0.0001191597,0.001202657,0.0003513824,0.0007260924,0.002815037],"genre_scores_gemma":[0.967294,0.00004909233,0.03013685,0.0005995816,0.0002727163,0.0002473761,0.000461698,0.0001121808,0.0008264551],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01516199,"threshold_uncertainty_score":0.9998131,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02081796993495172,"score_gpt":0.2201285951604307,"score_spread":0.1993106252254789,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}