{"id":"W4246592208","doi":"10.1007/s00277-020-04280-3","title":"Direct comparison of two extended half-life PEGylated recombinant FVIII products: a randomized, crossover pharmacokinetic study in patients with severe hemophilia A","year":2020,"lang":"en","type":"article","venue":"Annals of Hematology","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Impact","funders":"Bayer","keywords":"Pharmacokinetics; Medicine; Crossover study; Certolizumab pegol; Bioequivalence; Pharmacology; NONMEM; Adverse effect; Dosing; Internal medicine; Placebo","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003629585,0.001654402,0.004777781,0.0005172493,0.0004704545,0.001246769,0.0008526398,0.00181343,0.00380201],"category_scores_gemma":[0.003542002,0.001013448,0.002240395,0.0005652334,0.001747314,0.00159748,0.0004759065,0.002642628,0.0007726122],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007634887,"about_ca_system_score_gemma":0.001227937,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004708334,"about_ca_topic_score_gemma":0.0006044515,"domain_scores_codex":[0.9975607,0.001360698,0.0001735897,0.0004866646,0.000184957,0.0002333566],"domain_scores_gemma":[0.9964641,0.001147435,0.0008129873,0.0005005521,0.0002216906,0.0008531787],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.972132,0.01318628,0.001054373,0.0001588819,0.0004984283,0.0000358627,0.00006806758,0.0002458041,0.005409145,0.00007616987,0.0001321087,0.007002811],"study_design_scores_gemma":[0.5664281,0.4283234,0.003168747,0.000009597942,0.0003691217,0.000041947,0.00002651634,0.000486055,0.0006660367,0.00008272433,0.0003763786,0.00002127174],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956784,0.0008822292,0.0007362459,0.0001030383,0.0001615623,0.001789637,0.00025859,0.0000425211,0.0003477561],"genre_scores_gemma":[0.9940087,0.0005613211,0.001680067,0.0002685961,0.0003177201,0.002156495,0.0003348485,0.0000140138,0.0006583778],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004777781,"threshold_uncertainty_score":0.01919526,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06846704112382167,"score_gpt":0.386363915627459,"score_spread":0.3178968745036373,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}