{"id":"W4246592208","doi":"10.1007/s00277-020-04280-3","title":"Direct comparison of two extended half-life PEGylated recombinant FVIII products: a randomized, crossover pharmacokinetic study in patients with severe hemophilia A","year":2020,"lang":"en","type":"article","venue":"Annals of Hematology","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Impact","funders":"Bayer","keywords":"Pharmacokinetics; Medicine; Crossover study; Certolizumab pegol; Bioequivalence; Pharmacology; NONMEM; Adverse effect; Dosing; Internal medicine; Placebo","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003867301,0.0002750615,0.002278172,0.0002199289,0.00003838776,0.000006101018,0.0001631868,0.00008779209,0.0001297733],"category_scores_gemma":[0.0008281987,0.0001803023,0.0001404997,0.0006575722,0.000308965,0.00006972513,0.00009237885,0.0002782871,0.00001359774],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001167349,"about_ca_system_score_gemma":0.0001971437,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001316336,"about_ca_topic_score_gemma":0.00001167437,"domain_scores_codex":[0.9971262,0.0004381631,0.0009818559,0.0004978388,0.0005163072,0.0004395854],"domain_scores_gemma":[0.9983386,0.0002761341,0.0003500069,0.00034126,0.0004724527,0.0002215662],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.2203584,0.0106751,0.7607353,0.0008593699,0.001169716,0.0002085992,0.003174993,0.00003110965,0.0004892835,0.00006578325,0.00165515,0.0005771231],"study_design_scores_gemma":[0.7891043,0.01121435,0.1076394,0.0006154616,0.0007116285,0.0000484774,0.0007282689,0.001190071,0.08792511,0.0001144347,0.0001891861,0.0005192264],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885032,0.0009235932,0.000001832242,0.006468471,0.0000635746,0.003325417,0.000009156144,0.00003196985,0.0006727389],"genre_scores_gemma":[0.9993345,0.00005608171,0.00009011613,0.0002503615,0.00002003806,0.00008293414,0.00004089897,0.00003046262,0.00009461436],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6530959,"threshold_uncertainty_score":0.7352514,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06846704112382167,"score_gpt":0.386363915627459,"score_spread":0.3178968745036373,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}