{"id":"W4246615405","doi":"10.4081/oncol.2010.1","title":"Sequencing or not sequencing multikinase inhibitors in kidney cancer: this is the dilemma","year":2011,"lang":"en","type":"article","venue":"Oncology Reviews","topic":"Renal cell carcinoma treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Hospital Foundation","funders":"","keywords":"Medicine; Temsirolimus; Sunitinib; Pazopanib; Sorafenib; Everolimus; Bevacizumab; Kidney cancer; Oncology; Renal cell carcinoma; Internal medicine; Cancer; Clinical trial; Pharmacology; Discovery and development of mTOR inhibitors; Hepatocellular carcinoma; PI3K/AKT/mTOR pathway; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.03009673,0.0005721241,0.002014567,0.000528286,0.0007631592,0.002064082,0.001434828,0.00394244,0.002538749],"category_scores_gemma":[0.04115891,0.0002761858,0.0007097895,0.0008196067,0.002604893,0.006614653,0.0009712605,0.008449193,0.002124747],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001035174,"about_ca_system_score_gemma":0.003967852,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001528074,"about_ca_topic_score_gemma":0.003554061,"domain_scores_codex":[0.9941806,0.003221469,0.0008684823,0.0004866274,0.001056576,0.0001863008],"domain_scores_gemma":[0.959573,0.02898609,0.002062789,0.001583476,0.004984564,0.002810164],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000729239,0.0001671261,0.002746671,0.001765246,0.0002787431,0.0003496922,0.00046185,0.001628648,0.001167304,0.01551036,0.2053664,0.7698287],"study_design_scores_gemma":[0.0008428913,0.001838706,0.005183904,0.007060646,0.0006968807,0.00485003,0.002033558,0.003975119,0.002152798,0.2892588,0.6819134,0.0001933832],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.00528562,0.2157472,0.007701666,0.7596595,0.006804447,0.00003600326,0.0001038747,0.0001359777,0.004525644],"genre_scores_gemma":[0.1177431,0.3934866,0.03276239,0.4044773,0.04533381,0.0001830872,0.0002217444,0.0002829198,0.005509027],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.03009673,"threshold_uncertainty_score":0.1591686,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1926354421261995,"score_gpt":0.3614763324986894,"score_spread":0.1688408903724899,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}