{"id":"W4246615405","doi":"10.4081/oncol.2010.1","title":"Sequencing or not sequencing multikinase inhibitors in kidney cancer: this is the dilemma","year":2011,"lang":"en","type":"article","venue":"Oncology Reviews","topic":"Renal cell carcinoma treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Hospital Foundation","funders":"","keywords":"Medicine; Temsirolimus; Sunitinib; Pazopanib; Sorafenib; Everolimus; Bevacizumab; Kidney cancer; Oncology; Renal cell carcinoma; Internal medicine; Cancer; Clinical trial; Pharmacology; Discovery and development of mTOR inhibitors; Hepatocellular carcinoma; PI3K/AKT/mTOR pathway; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001204396,0.000332926,0.001041731,0.0001332865,0.0001138324,0.000009410805,0.0002200785,0.000217437,0.002596169],"category_scores_gemma":[0.0006119281,0.0001749366,0.0002543732,0.0004201145,0.0001749572,0.0001029417,0.0001021799,0.0005273092,0.0004352134],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003038414,"about_ca_system_score_gemma":0.001593753,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005992399,"about_ca_topic_score_gemma":0.001582255,"domain_scores_codex":[0.9974634,0.0004697095,0.0008660603,0.0005041038,0.0002065344,0.0004901863],"domain_scores_gemma":[0.9983955,0.0001699138,0.0003661442,0.0006847823,0.00008749649,0.0002961647],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.003035419,0.0009287586,0.1747243,0.003037542,0.0004890445,0.01052199,0.06053812,0.000004440703,0.08548846,0.0003012172,0.1172935,0.5436372],"study_design_scores_gemma":[0.003194215,0.001535944,0.008233103,0.00284765,0.0006539118,0.0008538514,0.0005828538,0.0001355556,0.05849352,0.00003045175,0.923016,0.0004229303],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9276125,0.0226711,0.00000822705,0.005099016,0.0009102998,0.004260838,0.00002305581,0.00008519661,0.03932979],"genre_scores_gemma":[0.9268712,0.03104059,0.005677839,0.0272433,0.0006306583,0.001746418,0.00002147696,0.00008948889,0.006679061],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8057225,"threshold_uncertainty_score":0.9983156,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1926354421261995,"score_gpt":0.3614763324986894,"score_spread":0.1688408903724899,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}