{"id":"W4246650330","doi":"10.1016/j.neuint.2021.104980","title":"The brain in flux: Genetic, physiologic, and therapeutic perspectives on transporters in the CNS","year":2021,"lang":"en","type":"editorial","venue":"Neurochemistry International","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"National Institute of Neurological Disorders and Stroke; National Institutes of Health; Agence Nationale de la Recherche","keywords":"Transporter; Neuroscience; Brain function; Function (biology); Biology; Computational biology; Excitatory amino-acid transporter; Neurochemistry; Membrane transport protein; Medicine; Bioinformatics; Gene; Neurology; Genetics; Excitatory postsynaptic potential","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003065343,0.0002763515,0.0001980588,0.00009863402,0.0002032974,0.0002107517,0.001651667,0.0002034194,0.00007096497],"category_scores_gemma":[0.002203719,0.0001807682,0.00009100176,0.0003124113,0.0006479468,0.00004997368,0.0001187663,0.001977989,0.00000609421],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000662912,"about_ca_system_score_gemma":0.0002010056,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003698853,"about_ca_topic_score_gemma":0.000007428886,"domain_scores_codex":[0.9966974,0.0004868628,0.0002969337,0.001025441,0.0010846,0.0004087856],"domain_scores_gemma":[0.9942755,0.005155535,0.0001093682,0.000347081,0.00006451617,0.00004802801],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001669136,0.0001910264,0.00004184967,0.00001326571,0.000004507895,0.0007404846,0.0004848779,0.00003312672,0.8940749,0.00005609583,0.1037728,0.0004202563],"study_design_scores_gemma":[0.002214728,0.0004376772,0.003978218,0.00008795304,0.00001770711,0.0001124973,0.001639114,0.0005910072,0.3928634,0.0003483956,0.5970708,0.0006385119],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8200194,0.0002338435,9.887042e-7,0.01069028,0.166,0.0004112756,0.0001187807,0.0000273531,0.002498154],"genre_scores_gemma":[0.9171765,0.00246397,8.376752e-7,0.003179896,0.07531914,0.0001439837,0.00001296602,0.00003131562,0.001671411],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5012115,"threshold_uncertainty_score":0.8593485,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02549412630255143,"score_gpt":0.34145362023348,"score_spread":0.3159594939309286,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}