{"id":"W4246656709","doi":"10.1200/jco.2021.39.15_suppl.tps4596","title":"PROSPER: Phase III RandOmized Study Comparing PERioperative nivolumab versus observation in patients with renal cell carcinoma (RCC) undergoing nephrectomy (ECOG-ACRIN EA8143).","year":2021,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Renal cell carcinoma treatment","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Kidney Foundation of Canada; Princess Margaret Cancer Centre; University Health Network; University of Calgary; McMaster University; Juravinski Cancer Centre","funders":"Bristol-Myers Squibb Canada; National Institutes of Health","keywords":"Medicine; Nivolumab; Renal cell carcinoma; Nephrectomy; Perioperative; Internal medicine; Neoadjuvant therapy; Kidney cancer; Oncology; Adjuvant; Stage (stratigraphy); Surgery; Urology; Immunotherapy; Kidney; Cancer; Breast cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002799551,0.001777412,0.002798935,0.0003648727,0.0004746443,0.001048546,0.0009981447,0.001750229,0.009174732],"category_scores_gemma":[0.002763419,0.0006143147,0.003043344,0.0004818396,0.0009441323,0.00108214,0.0006721491,0.003059982,0.00126096],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001036371,"about_ca_system_score_gemma":0.001862805,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0019718,"about_ca_topic_score_gemma":0.005045002,"domain_scores_codex":[0.9989409,0.0006790329,0.00005993944,0.000155425,0.00006411794,0.0001007315],"domain_scores_gemma":[0.9988865,0.000308862,0.0003740855,0.00009427081,0.00008265089,0.0002535665],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9827755,0.002224226,0.0006762818,0.001588056,0.001504449,0.00001898062,0.00002585052,0.0002329536,0.0008197167,0.0001121357,0.001550969,0.008470894],"study_design_scores_gemma":[0.9620082,0.03304107,0.002078646,0.000110778,0.0009189513,0.0000268162,0.00002186742,0.0001780506,0.0001766473,0.0002138819,0.001211845,0.00001330735],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9175235,0.0277752,0.002428785,0.002440986,0.0027251,0.02728519,0.01140004,0.0003698381,0.008051326],"genre_scores_gemma":[0.9510967,0.007859183,0.004581721,0.00318131,0.0007904725,0.02101168,0.00429312,0.00006532384,0.007120433],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009174732,"threshold_uncertainty_score":0.03069252,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1173438042269256,"score_gpt":0.4072556489342378,"score_spread":0.2899118447073121,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}