{"id":"W4246701592","doi":"10.1200/jco.2020.38.15_suppl.tps5596","title":"A multicenter, randomized, controlled phase II study: Efficacy and safety of PSMA-targeted radioligand therapy I-131-1095 (1095) plus enzalutamide (enza) in 18F-DCFPyL PSMA scan avid, metastatic castration-resistant prostate cancer (mCRPC) patients post-abiraterone (abi) progression (ARROW).","year":2020,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal; Université de Sherbrooke; Jewish General Hospital; Université Laval; St Joseph's Health Care","funders":"","keywords":"Medicine; Enzalutamide; Prostate cancer; Oncology; Internal medicine; Cancer; Androgen receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00363213,0.002467874,0.003304165,0.0004213077,0.0007652354,0.001662323,0.001431924,0.002204228,0.007779277],"category_scores_gemma":[0.002393344,0.0011882,0.001639738,0.0006051773,0.002248673,0.001691014,0.0004889356,0.00370109,0.001668487],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001340554,"about_ca_system_score_gemma":0.0026506,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001457665,"about_ca_topic_score_gemma":0.00255364,"domain_scores_codex":[0.9986584,0.0006958622,0.00007383143,0.0002765816,0.00009175885,0.000203521],"domain_scores_gemma":[0.9980489,0.0003627001,0.0004417686,0.0001980992,0.0001483677,0.000800156],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9726035,0.01537426,0.0007156397,0.0002035855,0.000426637,0.00003269865,0.00005624323,0.0002062399,0.003878949,0.00006419754,0.0005652835,0.005872632],"study_design_scores_gemma":[0.863808,0.1328788,0.00175751,0.00001123083,0.0002563125,0.00003079963,0.00002116352,0.0002516512,0.0003804764,0.00007408282,0.0005174589,0.0000125933],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9838768,0.001886082,0.001053059,0.0005794797,0.0004887859,0.00889095,0.001346645,0.0001541347,0.001724167],"genre_scores_gemma":[0.974921,0.001631314,0.002921878,0.001502797,0.0007637033,0.01175272,0.002069148,0.00006769599,0.004369715],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007779277,"threshold_uncertainty_score":0.02602422,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08489063859828656,"score_gpt":0.4675145738132983,"score_spread":0.3826239352150118,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}