{"id":"W4246916336","doi":"10.21203/rs.3.rs-25157/v1","title":"Depressive Effectiveness of Vigabatrin (y-Vinyl-GABA), an Antiepileptic Drug, in Intermediate-conductance Calcium-Activated Potassium Channels in Human Glioma Cells","year":2020,"lang":"en","type":"preprint","venue":"Research Square","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Cheng Kung University Hospital; National Cheng Kung University; Ministry of Science and Technology, Taiwan","keywords":"Vigabatrin; Conductance; Potassium; Glioma; Calcium-activated potassium channel; Calcium; Human brain; Antiepileptic drug; Drug; Neuroscience; Pharmacology; Chemistry; Epilepsy; Medicine; Psychology; Anticonvulsant; Cancer research; Physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008096887,0.0001833354,0.0002385074,0.0001092778,0.00008327093,0.0002394687,0.0001919068,0.0002547598,0.0007754937],"category_scores_gemma":[0.00009342935,0.00008031056,0.0002247568,0.0001233225,0.0001275227,0.0001558059,0.0001236414,0.0003360389,0.000218963],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002381283,"about_ca_system_score_gemma":0.0001414012,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001494906,"about_ca_topic_score_gemma":0.001157949,"domain_scores_codex":[0.9998853,0.00001917808,0.00001506345,0.00002233559,0.0000251155,0.00003295558],"domain_scores_gemma":[0.999966,0.00000646448,0.000006391336,0.000004401755,0.000004948733,0.00001160744],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002853409,0.00003662741,0.0002941895,0.00004611753,0.000007090667,0.00005298172,0.00001963293,0.00004707441,0.99815,0.00006804506,0.00005857912,0.0009343383],"study_design_scores_gemma":[0.00008543608,0.001301333,0.01763108,0.00001147711,0.00003611876,0.0002698461,0.00009805089,0.00149342,0.9772101,0.0000601525,0.001795388,0.00000771433],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963681,0.001724687,0.0004665931,0.000054006,0.00002879205,0.00001130165,0.0003189003,0.00002773487,0.001000013],"genre_scores_gemma":[0.9982921,0.0005974283,0.0002774289,0.00003540479,0.000003833689,0.00001440684,0.0002399432,0.000002653309,0.0005367965],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001494906,"threshold_uncertainty_score":0.002972364,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1208263422040452,"score_gpt":0.4365052494327398,"score_spread":0.3156789072286946,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}