{"id":"W4246974277","doi":"10.26434/chemrxiv-2021-nk95v-v2","title":"The Total Synthesis of Proposed Immunoactive Glycolipids from S. Pneumoniae and a Re-evaluation of Their Immunological Activity","year":2021,"lang":"en","type":"preprint","venue":"ChemRxiv","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Windsor","funders":"Natural Sciences and Engineering Research Council of Canada; Windsor Cancer Centre Foundation; Compute Canada; University of Windsor","keywords":"CD1D; Glycolipid; Ceramide; Glycosphingolipid; Biology; Antigen; Natural killer T cell; Immune system; Receptor; Major histocompatibility complex; Streptococcus pneumoniae; T-cell receptor; Immunology; Cell biology; Biochemistry; Bacteria; T cell; Genetics; Apoptosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001465679,0.0005293079,0.0003685677,0.0001898884,0.000184092,0.0006484752,0.0003568335,0.0003742386,0.00191835],"category_scores_gemma":[0.0002475754,0.0001748148,0.0006102708,0.0002834266,0.000215686,0.0004686282,0.0002933415,0.0005665878,0.0008935414],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000430474,"about_ca_system_score_gemma":0.0005611216,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007738338,"about_ca_topic_score_gemma":0.0007763725,"domain_scores_codex":[0.9999095,0.00001105688,0.000004483124,0.00002013893,0.00003344036,0.00002125737],"domain_scores_gemma":[0.999945,0.00001073434,0.00001030011,0.00001061178,0.00001272886,0.00001062745],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005278536,0.0001321376,0.0009060485,0.001535164,0.0000722038,0.0004385628,0.00009570012,0.02716126,0.9264312,0.006002446,0.0007403491,0.03595702],"study_design_scores_gemma":[0.00005291571,0.0005274338,0.0005792926,0.00004588242,0.00007663295,0.0002226811,0.00005178139,0.02320122,0.9528764,0.001580618,0.02075728,0.00002788055],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9491815,0.005341473,0.03210839,0.0003000551,0.0001857779,0.0000921151,0.002465663,0.0003356773,0.009989373],"genre_scores_gemma":[0.9288217,0.005024415,0.05810918,0.00007681717,0.00001966299,0.0001188547,0.002453579,0.0001757952,0.00519979],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00191835,"threshold_uncertainty_score":0.006417513,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02615113176636051,"score_gpt":0.2555189226689768,"score_spread":0.2293677909026163,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}