{"id":"W4247072955","doi":"10.2196/preprints.30163","title":"The Safety, Clinical, and Neurophysiological Effects of Intranasal Ketamine in Patients Who Do Not Respond to Electroconvulsive Therapy: Protocol for a Pilot, Open-Label Clinical Trial (Preprint)","year":2021,"lang":"en","type":"preprint","venue":"","topic":"Treatment of Major Depression","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Electroconvulsive therapy; Treatment-resistant depression; Ketamine; Medicine; Depression (economics); Major depressive disorder; Transcranial magnetic stimulation; Clinical trial; Antidepressant; Pharmacotherapy; Anesthesia; Psychiatry; Internal medicine; Stimulation; Hippocampus; Mood","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01154995,0.004408351,0.006405654,0.001212642,0.002665475,0.002098747,0.002676736,0.004744713,0.06751875],"category_scores_gemma":[0.01161081,0.001989544,0.003524013,0.00155314,0.002599648,0.002560803,0.00140748,0.007069781,0.01433445],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002708697,"about_ca_system_score_gemma":0.009199446,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001438961,"about_ca_topic_score_gemma":0.003071385,"domain_scores_codex":[0.9955674,0.00201994,0.0005864868,0.0005788462,0.0005432272,0.0007040856],"domain_scores_gemma":[0.9938094,0.00109673,0.001066497,0.0009696546,0.00159705,0.00146079],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8780242,0.05906753,0.0006762515,0.005864518,0.0006220675,0.0002778896,0.0002634249,0.001423461,0.006127778,0.001334155,0.01508617,0.03123261],"study_design_scores_gemma":[0.7991785,0.1672989,0.003375295,0.000879487,0.0004088171,0.00009860953,0.0001162253,0.0007175319,0.00131016,0.001277755,0.02524178,0.00009706628],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.01189745,0.0003952423,0.00135164,0.0002818549,0.000409652,0.9821408,0.001720126,0.0001005138,0.001702706],"genre_scores_gemma":[0.008980214,0.0003151397,0.002006163,0.0003590304,0.0001439699,0.9866534,0.0005252343,0.00001107148,0.001005822],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.06751875,"threshold_uncertainty_score":0.2258727,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1312025286476021,"score_gpt":0.4632737551626271,"score_spread":0.3320712265150251,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}