{"id":"W4247073036","doi":"10.1016/j.bcp.2014.08.023","title":"Identification of transmembrane domain 1 &amp; 2 residues that contribute to the formation of the ligand-binding pocket of the urotensin-II receptor","year":2014,"lang":"en","type":"article","venue":"Biochemical Pharmacology","topic":"Cardiovascular, Neuropeptides, and Oxidative Stress Research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Sherbrooke","funders":"Canadian Institutes of Health Research","keywords":"Urotensin-II; Transmembrane domain; Identification (biology); Transmembrane protein; Ligand (biochemistry); Chemistry; Receptor; Domain (mathematical analysis); Biophysics; Computational biology; Biology; Biochemistry; Mathematics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009458627,0.000111088,0.0003355721,0.0000629531,0.0001155706,0.000005005627,0.0003590511,0.00008554477,0.00005571404],"category_scores_gemma":[0.0005148674,0.00005721581,0.0002959572,0.0003378691,0.0003905743,0.00003694129,0.0001561276,0.0002334582,0.000007888253],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003715597,"about_ca_system_score_gemma":0.00004731692,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001568272,"about_ca_topic_score_gemma":0.000003124749,"domain_scores_codex":[0.9982212,0.0004901655,0.0004274887,0.0001861672,0.0004730051,0.0002019382],"domain_scores_gemma":[0.9986914,0.0002656548,0.0002295339,0.0004356424,0.0003155339,0.00006221484],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004343521,0.00006480073,0.0001476091,0.0001405796,0.0001015236,1.694424e-7,0.0004263109,0.000009974669,0.9525201,0.00002646041,0.04585563,0.0002724408],"study_design_scores_gemma":[0.001275119,0.00007342621,0.004309684,0.0000815172,0.0001665747,0.00001113341,0.00006172446,0.0000278293,0.9712241,0.00003370121,0.02268329,0.00005192632],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9902965,0.0004742409,0.0004192913,0.007350185,0.0002785072,0.0009541871,0.00008133635,0.000008549859,0.0001371547],"genre_scores_gemma":[0.9989695,0.0001536437,0.00004177484,0.0004001091,0.0001517934,0.0000260439,0.00002093691,0.000012056,0.0002241182],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02317234,"threshold_uncertainty_score":0.2333193,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02555558286079832,"score_gpt":0.3081683672762419,"score_spread":0.2826127844154435,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}