{"id":"W4247089920","doi":"10.21203/rs.2.13361/v2","title":"A three-arm, multicenter, open-label randomized controlled trial of hydroxychloroquine and low-dose prednisone on recurrent spontaneous abortion with undifferentiated connective tissue diseases: Protocol for the immunosuppressant regimens for Living FEtuses (ILIFE) Trial","year":2020,"lang":"en","type":"preprint","venue":"Research Square","topic":"Reproductive System and Pregnancy","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Impact","funders":"","keywords":"Hydroxychloroquine; Medicine; Prednisone; Connective tissue; Abortion; Open label; Randomized controlled trial; Internal medicine; Surgery; Pathology; Pregnancy; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0107289,0.003250362,0.006010318,0.0006562871,0.001488516,0.002365299,0.002151274,0.004577103,0.0158199],"category_scores_gemma":[0.01130566,0.001125554,0.003770746,0.0008476583,0.001811603,0.001915585,0.0009350071,0.0052269,0.002339229],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001662745,"about_ca_system_score_gemma":0.00467452,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001384972,"about_ca_topic_score_gemma":0.002735494,"domain_scores_codex":[0.9938113,0.004249363,0.0004368634,0.0005490495,0.0004557908,0.0004977531],"domain_scores_gemma":[0.9946555,0.001256998,0.001478499,0.0005592221,0.0007817223,0.001268126],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9879701,0.003742894,0.000323836,0.001252517,0.001057029,0.00003240861,0.00004871701,0.0001643671,0.0005412245,0.000183491,0.001435894,0.003247548],"study_design_scores_gemma":[0.9898342,0.008426762,0.0004268063,0.00006625687,0.0002900375,0.000009302812,0.00001111184,0.0002051119,0.00008721778,0.0001028346,0.0005305979,0.000009801432],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.3135727,0.007539411,0.005078284,0.005791167,0.003562772,0.6449975,0.01169353,0.0006888027,0.007075863],"genre_scores_gemma":[0.3172852,0.002463677,0.009174623,0.004588342,0.0009170612,0.6553829,0.004000816,0.00006149674,0.006125802],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.0158199,"threshold_uncertainty_score":0.05674052,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08077926329970797,"score_gpt":0.4099608860791196,"score_spread":0.3291816227794117,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}