{"id":"W4247288199","doi":"10.1182/blood.v118.21.767.767","title":"Results of the OPAL Study: A Phase II Study to Evaluate the Efficacy, Safety and Tolerability of Tosedostat (CHR-2797) in Elderly Subjects with Treatment Refractory or Relapsed Acute Myeloid Leukemia","year":2011,"lang":"en","type":"article","venue":"Blood","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Tolerability; Internal medicine; Refractory (planetary science); Cytarabine; Gastroenterology; Adverse effect; Hypomethylating agent; Neutropenia; Febrile neutropenia; Nausea; Phases of clinical research; Randomized controlled trial; Myeloid leukemia; Surgery; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002063081,0.001022395,0.001337791,0.0002513401,0.0002462425,0.0006011197,0.0005116645,0.0006040481,0.002691513],"category_scores_gemma":[0.0009647664,0.0003342098,0.0009263296,0.0002502927,0.0008644587,0.0006193515,0.0003333007,0.00177983,0.0005217616],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004015654,"about_ca_system_score_gemma":0.0009830035,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003728865,"about_ca_topic_score_gemma":0.0008848023,"domain_scores_codex":[0.999478,0.0002849573,0.00002867441,0.00006230533,0.00006269957,0.00008336618],"domain_scores_gemma":[0.9991036,0.0001784602,0.000187216,0.00007059574,0.00005781457,0.000402269],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.870356,0.04383053,0.01544519,0.0006037601,0.001416198,0.0002879795,0.0002017295,0.0009976295,0.02293948,0.0001837752,0.001647601,0.04209015],"study_design_scores_gemma":[0.4977904,0.4688033,0.02696624,0.00002915188,0.0008805151,0.0002570115,0.00006935887,0.0004729215,0.002537894,0.0001117035,0.00205459,0.00002691371],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962412,0.0007358691,0.0002571344,0.000129983,0.00003392673,0.001108953,0.0006669884,0.0000220232,0.0008038376],"genre_scores_gemma":[0.9927465,0.0008880376,0.0009281488,0.000474128,0.0001320892,0.001636532,0.001674022,0.00001496321,0.001505634],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002691513,"threshold_uncertainty_score":0.01091075,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03373182040978893,"score_gpt":0.3099555019742059,"score_spread":0.276223681564417,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}