{"id":"W4247288199","doi":"10.1182/blood.v118.21.767.767","title":"Results of the OPAL Study: A Phase II Study to Evaluate the Efficacy, Safety and Tolerability of Tosedostat (CHR-2797) in Elderly Subjects with Treatment Refractory or Relapsed Acute Myeloid Leukemia","year":2011,"lang":"en","type":"article","venue":"Blood","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Tolerability; Internal medicine; Refractory (planetary science); Cytarabine; Gastroenterology; Adverse effect; Hypomethylating agent; Neutropenia; Febrile neutropenia; Nausea; Phases of clinical research; Randomized controlled trial; Myeloid leukemia; Surgery; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008787984,0.0002215839,0.0006412012,0.0001135396,0.0001219211,0.000006758419,0.0001392543,0.00004224863,0.00003860761],"category_scores_gemma":[0.0002320987,0.00009886569,0.0001004034,0.0005601068,0.0001365206,0.00004709022,0.00009205432,0.0001709737,0.000001370072],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001139627,"about_ca_system_score_gemma":0.0003472609,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001522716,"about_ca_topic_score_gemma":0.004873333,"domain_scores_codex":[0.9978209,0.0004336502,0.0006800706,0.0004087273,0.0004543814,0.0002022648],"domain_scores_gemma":[0.9985245,0.0001858161,0.0001632384,0.0008565807,0.000151715,0.0001180745],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"qualitative","study_design_gemma":"observational","study_design_scores_codex":[0.1974155,0.2356948,0.1506644,0.000139483,0.005784724,0.0008143812,0.3023419,0.00004698723,0.0827627,0.00001011414,0.0001115692,0.02421335],"study_design_scores_gemma":[0.1626491,0.1108201,0.6541025,0.000489802,0.003784665,0.00004000123,0.01575619,0.00003688399,0.05199216,0.000005530713,0.00007608693,0.0002469851],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967779,0.00002361017,0.000001647735,0.0002432753,0.00001199167,0.002441043,0.00007851806,0.00001764725,0.0004043698],"genre_scores_gemma":[0.9994381,0.00001411959,0.00005860101,0.00006776146,0.00001946507,0.00005201401,0.00000915004,0.00001500674,0.0003257458],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5034381,"threshold_uncertainty_score":0.4031626,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03373182040978893,"score_gpt":0.3099555019742059,"score_spread":0.276223681564417,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}