{"id":"W4247419846","doi":"10.32920/ryerson.14665677","title":"Development of enantioselective intramolecular N-arylation reactions for the desymmetrization of achiral dinitrogen malonamide derivatives","year":2021,"lang":"en","type":"preprint","venue":"","topic":"Asymmetric Synthesis and Catalysis","field":"Chemistry","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Metropolitan University","funders":"","keywords":"Desymmetrization; Chemistry; Enantioselective synthesis; Intramolecular force; Enantiopure drug; Nucleophile; Yield (engineering); Substituent; Derivative (finance); Medicinal chemistry; Enantiomer; Stereochemistry; Organic chemistry; Catalysis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004759827,0.0006822976,0.000301042,0.0002285949,0.0001284585,0.0002190708,0.0005512239,0.0002648548,0.001140132],"category_scores_gemma":[0.0002726369,0.0002063983,0.0002646915,0.0001764676,0.0002221034,0.0003176429,0.0003862828,0.0007145845,0.0006057214],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003053629,"about_ca_system_score_gemma":0.0002891573,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004274533,"about_ca_topic_score_gemma":0.001134836,"domain_scores_codex":[0.9997558,0.00004711508,0.0000243576,0.00005656031,0.00006064998,0.00005551851],"domain_scores_gemma":[0.9999223,0.00001254089,0.00002218431,0.00001790786,0.00001160277,0.00001359487],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006428765,0.00005030831,0.0002025554,0.0001796596,0.00002366321,0.0002679856,0.00008265285,0.0003159859,0.9876124,0.001141139,0.0001055301,0.009953833],"study_design_scores_gemma":[0.00001345643,0.0001806142,0.000353216,0.00000464681,0.00001288159,0.0003129725,0.00001209029,0.0005306642,0.9949733,0.00005778774,0.003539975,0.000008406025],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8970981,0.003676635,0.08243542,0.000179147,0.00008798018,0.0003046262,0.0004315283,0.0003658491,0.01542075],"genre_scores_gemma":[0.9613028,0.002593879,0.03172779,0.00005041649,0.00002522372,0.0001028948,0.0004010815,0.00005996255,0.003735914],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001140132,"threshold_uncertainty_score":0.003814101,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02537912271840666,"score_gpt":0.2626399257725523,"score_spread":0.2372608030541456,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}