{"id":"W4247681342","doi":"10.17504/protocols.io.rv3d68n","title":"Global Standards for Biosimilars v1","year":2018,"lang":"en","type":"preprint","venue":"","topic":"Biosimilars and Bioanalytical Methods","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Biosimilar; Biopharmaceutical; Biological drugs; Business; Risk analysis (engineering); Pharmaceutical industry; Pharmacology; Biotechnology; Medicine","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0009946554,0.0004010444,0.0006552574,0.00006144183,0.0001537796,0.00005246071,0.0005505576,0.001717184,0.004077175],"category_scores_gemma":[0.0003639073,0.0002976622,0.0004738208,0.0001085047,0.0005560098,0.00002105556,0.0007854569,0.000367982,0.00007752294],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001999089,"about_ca_system_score_gemma":0.0004287941,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002617037,"about_ca_topic_score_gemma":0.00005512051,"domain_scores_codex":[0.9979795,0.000169507,0.0004449055,0.0007655725,0.00007049552,0.0005700686],"domain_scores_gemma":[0.9985141,0.0001445948,0.0001571511,0.0006316127,0.000502753,0.00004985672],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003873049,0.0001217528,0.0006863519,0.0001726403,0.0007574205,0.000001688401,0.00001415717,0.000001006328,0.001184764,0.004417245,0.9787186,0.01353701],"study_design_scores_gemma":[0.001025749,0.0004188087,0.0007774569,0.0001074748,0.0003517471,0.00001552592,0.00002687419,0.00003327978,0.02311488,0.03436847,0.9391862,0.0005735627],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.01435835,0.02685389,0.5353005,0.03186003,0.04406607,0.006843282,0.07070624,0.001719299,0.2682923],"genre_scores_gemma":[0.3913226,0.002364977,0.4604582,0.04371853,0.003994153,0.001078492,0.003872519,0.0003829967,0.09280751],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.3769642,"threshold_uncertainty_score":0.9999475,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03654376306522028,"score_gpt":0.3645606475434762,"score_spread":0.3280168844782559,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}