{"id":"W4247683679","doi":"10.12688/f1000research.5512.1","title":"Diversity of two-component systems: insights into the signal transduction mechanism by the Staphylococcus aureus two-component system GraSR","year":2014,"lang":"en","type":"preprint","venue":"F1000Research","topic":"Antimicrobial Resistance in Staphylococcus","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University","funders":"Natural Sciences and Engineering Research Council of Canada; Ministero dello Sviluppo Economico; Ontario Ministry of Economic Development and Innovation","keywords":"Response regulator; Histidine kinase; Autophosphorylation; Two-component regulatory system; ATP-binding cassette transporter; Signal transduction; Bacillus subtilis; Biology; Cell biology; Biochemistry; Histidine; HAMP domain; Protein kinase domain; Phosphorylation; Chemistry; Protein kinase A; Protein domain; Genetics; Transporter; Gene; Bacteria; Enzyme; Bacterial protein","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001474309,0.0004193178,0.0003364573,0.0003311653,0.0001544787,0.0004982107,0.0002164669,0.0004662719,0.0009016907],"category_scores_gemma":[0.0001541739,0.0001673681,0.0003718587,0.000155479,0.0002617328,0.0006112139,0.0003234146,0.0005277062,0.000369078],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005026152,"about_ca_system_score_gemma":0.0002371448,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004677853,"about_ca_topic_score_gemma":0.000380981,"domain_scores_codex":[0.9998696,0.00002654296,0.000009763326,0.00002919681,0.00004061102,0.00002428506],"domain_scores_gemma":[0.9999325,0.00001967694,0.0000138036,0.00001002316,0.00001066145,0.00001331549],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004580774,0.00002388649,0.0006283192,0.00007091642,0.000006641388,0.0001432277,0.00003548536,0.0008335229,0.992804,0.001465341,0.00004881216,0.003894089],"study_design_scores_gemma":[0.00006155577,0.0006803036,0.02104088,0.00004330403,0.00006119141,0.002522856,0.0003407058,0.06592822,0.8864438,0.006705975,0.01609407,0.00007718144],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9578968,0.004295311,0.03219323,0.0005564531,0.00003819272,0.00004271609,0.0001472484,0.0003288183,0.004501228],"genre_scores_gemma":[0.9853055,0.001197891,0.01192983,0.0001337178,0.00001227752,0.00002543883,0.0002249985,0.00002384252,0.001146546],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009016907,"threshold_uncertainty_score":0.003646731,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02712232541767215,"score_gpt":0.2932600764641405,"score_spread":0.2661377510464684,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}