{"id":"W4247708146","doi":"10.1158/1538-7445.fbcr11-a3","title":"Abstract A3: p53-dependent release of alarmin HMGB1 is a central mediator of senescent phenotypes","year":2011,"lang":"en","type":"article","venue":"Cancer Research","topic":"Advanced Glycation End Products research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine; Université de Montréal","funders":"","keywords":"Secretion; HMGB1; Biology; Senescence; Cell biology; Extracellular; Immunology; Inflammation; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001576747,0.000410195,0.00021901,0.000207457,0.0001379383,0.0002551244,0.0001386835,0.000268059,0.001975928],"category_scores_gemma":[0.0001045234,0.0001105654,0.0002091874,0.0001336202,0.0001810051,0.000170295,0.0002384164,0.000398572,0.00077226],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000200614,"about_ca_system_score_gemma":0.0001052867,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001507323,"about_ca_topic_score_gemma":0.00008940278,"domain_scores_codex":[0.9998943,0.00001596089,0.00001092985,0.00002896982,0.00002617704,0.000023657],"domain_scores_gemma":[0.9998482,0.00001289082,0.00005239796,0.00001232935,0.00001883488,0.00005524724],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001121219,0.000005243242,0.0002079395,0.00001614696,0.000002150431,0.00004734406,0.000004942613,0.000007641373,0.9992437,0.00003265601,0.00002398312,0.0002962652],"study_design_scores_gemma":[0.00002361651,0.0002980513,0.01481271,0.000007324928,0.00001365844,0.0007120988,0.0000248489,0.0004340361,0.9816278,0.0001298641,0.001911544,0.00000448398],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9895745,0.002898305,0.005257396,0.0001688707,0.00006125608,0.0000263157,0.0009288157,0.0001688001,0.0009159353],"genre_scores_gemma":[0.9948612,0.0005295312,0.001205098,0.00006146159,0.00002726499,0.00002589319,0.0008053054,0.0000165546,0.002467585],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001975928,"threshold_uncertainty_score":0.006610096,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07090157318661089,"score_gpt":0.3842560539290987,"score_spread":0.3133544807424878,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}