{"id":"W4247729913","doi":"10.1007/s00125-006-0157-z","title":"Insulin resistance causes increased beta-cell mass but defective glucose-stimulated insulin secretion in a murine model of type 2 diabetes","year":2006,"lang":"en","type":"article","venue":"Diabetologia","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Prince Edward Island; Canada Research Chairs; University of Toronto; University of New Brunswick","funders":"","keywords":"Insulin resistance; Endocrinology; Internal medicine; Beta cell; Human physiology; Secretion; Diabetes mellitus; Insulin; BETA (programming language); Type 2 diabetes; Insulin oscillation; Medicine; Type 1 diabetes; Biology; Islet","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007867691,0.002528989,0.0008069078,0.002535656,0.0005089141,0.00091565,0.001012568,0.001567695,0.002274832],"category_scores_gemma":[0.0004999214,0.001089971,0.000837171,0.0009593391,0.0013478,0.0007861374,0.0005901682,0.003021731,0.0007218063],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008157045,"about_ca_system_score_gemma":0.000383397,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005421718,"about_ca_topic_score_gemma":0.0007210294,"domain_scores_codex":[0.9992049,0.0002388176,0.00008844952,0.0001456938,0.0002019857,0.000120079],"domain_scores_gemma":[0.9990053,0.0001662348,0.0003542199,0.0001389375,0.0000316023,0.0003038079],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002409934,0.0005942166,0.0006654171,0.0000793179,0.00004002945,0.0007353066,0.000055636,0.0004624545,0.9928014,0.0007197393,0.0002071365,0.001229392],"study_design_scores_gemma":[0.001448861,0.007227342,0.01542319,0.0001154051,0.0002880896,0.005673449,0.0001868936,0.004996594,0.9590978,0.001099572,0.004362259,0.0000805598],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937075,0.001056493,0.002105068,0.000414713,0.0001079426,0.00006609424,0.000737814,0.0002851063,0.001519346],"genre_scores_gemma":[0.9889396,0.001802341,0.003894539,0.000233646,0.00008460718,0.0001608319,0.0009383095,0.0002073158,0.003738777],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002535656,"threshold_uncertainty_score":0.007610083,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01503463748045299,"score_gpt":0.2315484499165579,"score_spread":0.2165138124361049,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}