{"id":"W4247804710","doi":"10.3410/f.733852398.793550114","title":"Faculty Opinions recommendation of A selective inhibitor of ceramide synthase 1 reveals a novel role in fat metabolism.","year":2018,"lang":"en","type":"dataset","venue":"Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"National Health and Medical Research Council; Deakin University; University of New South Wales; Diabetes Australia; Medical Research Council; Australian Government","keywords":"Ceramide; Insulin resistance; Ceramide synthase; Adipose tissue; Sphingolipid; Skeletal muscle; Endocrinology; Internal medicine; Beta oxidation; Biochemistry; Fatty acid synthase; Biology; Lipid metabolism; Metabolism; Chemistry; Insulin; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.001075038,0.001913541,0.001416211,0.004137762,0.0007020142,0.00238416,0.00205581,0.001906049,0.0590103],"category_scores_gemma":[0.007908653,0.0004306361,0.001524923,0.006192462,0.000322202,0.001289156,0.001489536,0.001469542,0.05564151],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001361754,"about_ca_system_score_gemma":0.003434866,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01432259,"about_ca_topic_score_gemma":0.0391001,"domain_scores_codex":[0.9987133,0.0001921094,0.0001509711,0.0004178649,0.0003651956,0.0001606485],"domain_scores_gemma":[0.9972312,0.0009279489,0.0004400497,0.0004446945,0.0006179722,0.0003381226],"domain_codex":null,"domain_gemma":"evaluation","domain_candidate":"evaluation","domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002857755,0.0000382475,0.00441895,0.004626815,0.0002644467,0.00008374827,0.00004082016,0.0004032688,0.0009420522,0.0006806709,0.9751209,0.01309438],"study_design_scores_gemma":[0.0002317916,0.00002486902,0.006420663,0.0004453123,0.0001418116,0.00006985227,0.00003255602,0.0003337317,0.0007920219,0.0006804147,0.9908035,0.00002343527],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"dataset","genre_gemma":"dataset","genre_scores_codex":[0.0003625264,0.000547609,0.0001094837,0.0001860875,0.00005206397,0.00001847803,0.9964746,0.0004527101,0.001796461],"genre_scores_gemma":[0.001018239,0.0004103544,0.0004563622,0.0001214004,0.0000180506,0.00007107054,0.9968172,0.00007667259,0.001010692],"genre_candidate":"dataset","genre_consensus":"dataset","teacher_disagreement_score":0.998925,"threshold_uncertainty_score":0.1974091,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01946842679138839,"score_gpt":0.3269794252898913,"score_spread":0.3075109984985029,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}