{"id":"W4248028975","doi":"10.1002/ange.202005934","title":"Glycoengineering of NK Cells with Glycan Ligands of CD22 and Selectins for B‐Cell Lymphoma Therapy","year":2020,"lang":"en","type":"article","venue":"Angewandte Chemie","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institutes of Health; Danmarks Grundforskningsfond","keywords":"CD22; Selectin; Chemistry; Sialyl-Lewis X; Cancer research; Natural killer cell; Glycan; Lymphoma; Antigen; Immunology; Molecular biology; In vitro; Biology; CD20; Biochemistry; Cytotoxic T cell; Cell adhesion molecule; Glycoprotein","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007929403,0.0002268988,0.000098569,0.0001091552,0.00007233486,0.0001790201,0.0001057652,0.0001844135,0.0006926776],"category_scores_gemma":[0.00005157686,0.00005976395,0.0001112931,0.0000823871,0.0001138522,0.0001357317,0.0001743647,0.0002766248,0.0001459428],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002146027,"about_ca_system_score_gemma":0.0001184369,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004108856,"about_ca_topic_score_gemma":0.0005008189,"domain_scores_codex":[0.9999584,0.000009492398,0.000002106315,0.000005266608,0.00001200082,0.00001259973],"domain_scores_gemma":[0.9999849,0.000001561042,0.000004966879,0.000001936023,0.000002055786,0.000004569433],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005212813,0.00003046606,0.00008830205,0.00002918899,0.000005416579,0.00004695097,0.0000122328,0.0002343231,0.9954386,0.0004087151,0.00009787297,0.003555793],"study_design_scores_gemma":[0.00001884196,0.0002547365,0.0004241732,0.000003601202,0.00001127852,0.0002039346,0.000009370313,0.001275442,0.99339,0.00005439492,0.004350963,0.000003426516],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9813297,0.003725927,0.01047691,0.0002038805,0.00005596024,0.00007010905,0.00008230503,0.0001093077,0.003946072],"genre_scores_gemma":[0.9948285,0.001114061,0.002419713,0.00004349744,0.000007545326,0.00002408564,0.0000386441,0.000006454321,0.001517482],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006926776,"threshold_uncertainty_score":0.00231719,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02412454907267412,"score_gpt":0.257451623438061,"score_spread":0.2333270743653869,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}