{"id":"W4248072347","doi":"10.1158/1538-7445.am2019-3606","title":"Abstract 3606: Blockade of the PPARα metabolic checkpoint with TPST-1120 suppresses tumor growth and stimulates anti-tumor immunity","year":2019,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre","funders":"","keywords":"Cancer research; Tumor microenvironment; Melanoma; Ovarian cancer; Immune checkpoint; Pancreatic cancer; Biology; Immune system; Cancer; Immunotherapy; Medicine; Immunology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001435279,0.00068674,0.0004865199,0.0003076862,0.0001588496,0.0002723483,0.0002695796,0.0004597733,0.003529506],"category_scores_gemma":[0.00009380358,0.0002208461,0.0003164613,0.0002671021,0.0003245494,0.0002077256,0.000164626,0.001800263,0.0008534713],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002219613,"about_ca_system_score_gemma":0.0003653616,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004514972,"about_ca_topic_score_gemma":0.0005018517,"domain_scores_codex":[0.9998573,0.00002120495,0.00001584509,0.00002308973,0.00003824605,0.00004432373],"domain_scores_gemma":[0.999908,0.0000113033,0.00002263461,0.00001221244,0.000008011328,0.00003789807],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002362255,0.0005473971,0.0002471428,0.00009483421,0.00001555379,0.0000624309,0.00001941544,0.000343713,0.9906123,0.0001539521,0.0003679889,0.005172982],"study_design_scores_gemma":[0.0005368675,0.009513142,0.002550133,0.00001164689,0.00003646794,0.0003854548,0.00003125069,0.001612902,0.9822384,0.00006815389,0.00300748,0.000008051445],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993404,0.001206884,0.001321615,0.0002364042,0.0001284436,0.00008337025,0.0009456155,0.0003182028,0.002355459],"genre_scores_gemma":[0.9924719,0.0008799708,0.001381519,0.0001143366,0.00004026257,0.000104703,0.001330953,0.00002997933,0.003646438],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003529506,"threshold_uncertainty_score":0.01180744,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02132642519155866,"score_gpt":0.3142128799654107,"score_spread":0.2928864547738521,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}