{"id":"W4248174682","doi":"10.1021/pr070795+","title":"COMET and the Challenge of Drug Safety Screening","year":2007,"lang":"en","type":"article","venue":"Journal of Proteome Research","topic":"Science, Research, and Medicine","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"University of California, Los Angeles; School of Medicine, Vanderbilt University; Rijksuniversiteit Groningen; McGill University; University of Ottawa; National Cancer Institute; Carnegie Mellon University; Université de Genève; Vanderbilt University; Yale University; Imperial College London; North Carolina State University; Bristol-Myers Squibb; AstraZeneca; Lunds Universitet; Johns Hopkins University; Pfizer","keywords":"Drug; Comet; Medicine; Pharmacology; Astrobiology; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02875441,0.0009504501,0.005184995,0.003582637,0.002423009,0.00809769,0.00300668,0.007756869,0.007859357],"category_scores_gemma":[0.05933694,0.0006979905,0.00180718,0.002085623,0.008370304,0.008053717,0.004153498,0.01199349,0.002429542],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00341915,"about_ca_system_score_gemma":0.0035881,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001450609,"about_ca_topic_score_gemma":0.001390659,"domain_scores_codex":[0.9839184,0.005465097,0.0006098044,0.001382452,0.007620284,0.001004003],"domain_scores_gemma":[0.9357522,0.04061164,0.003770647,0.00517329,0.01174124,0.002951117],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002323009,0.0006712502,0.02390536,0.003241916,0.0007479626,0.002746757,0.001190996,0.00731314,0.03060898,0.3153983,0.1436573,0.468195],"study_design_scores_gemma":[0.0003803307,0.001770742,0.008465576,0.0008369483,0.0002792398,0.004609205,0.0017507,0.01182439,0.02352979,0.6529294,0.2933546,0.0002690226],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.06826387,0.1933588,0.0706704,0.6005003,0.0108583,0.0002749876,0.002013642,0.001512322,0.05254748],"genre_scores_gemma":[0.7238114,0.08914211,0.03190613,0.1173833,0.01622534,0.0004774336,0.002055839,0.0004346108,0.01856375],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.02875441,"threshold_uncertainty_score":0.1520697,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1198234117337652,"score_gpt":0.4529641828584249,"score_spread":0.3331407711246597,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}