{"id":"W4248193141","doi":"10.26434/chemrxiv.9275318","title":"Total Synthesis of (–)-Picrotoxinin","year":2019,"lang":"en","type":"preprint","venue":"ChemRxiv","topic":"Chemical synthesis and alkaloids","field":"Chemistry","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; Arnold and Mabel Beckman Foundation","keywords":"Stereochemistry; Chemistry; Demethylation; Total synthesis; Stereoselectivity; Bond cleavage; Bicyclic molecule; Counterintuitive; Geminal; Cleavage (geology); Biology; Organic chemistry; Catalysis; Philosophy; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001278029,0.0005574459,0.0002838544,0.0002844404,0.0002108567,0.0002540081,0.0003216974,0.0001703629,0.003344474],"category_scores_gemma":[0.0001017565,0.0001350322,0.0002013957,0.0003265678,0.0001702346,0.0003694295,0.0005305106,0.0004775658,0.002058043],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003150717,"about_ca_system_score_gemma":0.0004323548,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004734893,"about_ca_topic_score_gemma":0.0009635492,"domain_scores_codex":[0.9998672,0.0000106637,0.00001297125,0.0000328045,0.00003987507,0.00003634453],"domain_scores_gemma":[0.9999555,0.000002962866,0.000007752908,0.00000928207,0.0000110326,0.00001336373],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001232923,0.00007113654,0.0001696317,0.0005326482,0.00003844613,0.0005023552,0.0001714441,0.002314738,0.9440129,0.006051885,0.0009751741,0.0450363],"study_design_scores_gemma":[0.00005575129,0.001017178,0.001158268,0.00004096976,0.00005480389,0.00081669,0.00004490041,0.00132565,0.9313961,0.001577603,0.06247516,0.00003688746],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7430059,0.01013571,0.1499669,0.000532657,0.0005257523,0.0009414754,0.006411164,0.001247731,0.08723272],"genre_scores_gemma":[0.9497691,0.005455604,0.0247509,0.0001416786,0.00004321479,0.0001689454,0.001984894,0.0001162534,0.01756935],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003344474,"threshold_uncertainty_score":0.01118839,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0141933699734888,"score_gpt":0.2310786361531019,"score_spread":0.2168852661796131,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}