{"id":"W4248313354","doi":"10.1158/2643-3249.bcd-19-0039","title":"Persistence of Drug-Resistant Leukemic Stem Cells and Impaired NK Cell Immunity in CML Patients Depend on <i>MIR300</i> Antiproliferative and PP2A-Activating Functions","year":2020,"lang":"en","type":"article","venue":"Blood Cancer Discovery","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Maisonneuve-Rosemont","funders":"National Institutes of Health; Cancer Research Society; National Natural Science Foundation of China; American Cyronics Society; U.S. Department of Defense","keywords":"Progenitor cell; Protein phosphatase 2; Cancer research; Biology; Immune system; Stem cell; Immunology; Leukemia; Apoptosis; Cell biology; Phosphatase; Phosphorylation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007849424,0.0001677018,0.0002199553,0.0001725026,0.0001425486,0.0002325533,0.00008761321,0.0001531403,0.001284371],"category_scores_gemma":[0.0001037005,0.00009573728,0.0001498223,0.0001248058,0.0001399339,0.00009862466,0.0001038858,0.0003899942,0.000291327],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002017503,"about_ca_system_score_gemma":0.00014143,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002852695,"about_ca_topic_score_gemma":0.0004317187,"domain_scores_codex":[0.9999304,0.000007462662,0.00000727078,0.00001760738,0.00002194457,0.00001528945],"domain_scores_gemma":[0.9999517,0.000006558615,0.00001741973,0.000005340472,0.000004187349,0.00001485267],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006420716,0.00008053362,0.007335328,0.00003369535,0.00001335999,0.0002293118,0.00003067347,0.00009013552,0.9796229,0.0001375378,0.0002072693,0.01157721],"study_design_scores_gemma":[0.00009457803,0.001360957,0.1161719,0.000008883203,0.00006740634,0.004041061,0.0000719059,0.001051552,0.8703578,0.0002300842,0.006531092,0.00001273558],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964364,0.001263231,0.0007437398,0.00007104101,0.000009904102,0.00001795941,0.0002451206,0.00006994669,0.001142724],"genre_scores_gemma":[0.9980981,0.0003343976,0.0004601075,0.00005016076,0.000006872735,0.00001868722,0.0003655069,0.000007375092,0.0006588501],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001284371,"threshold_uncertainty_score":0.004296601,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01585045797614332,"score_gpt":0.2071715928590338,"score_spread":0.1913211348828905,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}