{"id":"W4248367574","doi":"10.1158/1538-7445.sabcs18-ct059","title":"Abstract CT059: A Phase Ib open label multicenter study with a HER2/neu peptide vaccine administered with cisplatin and 5-fluorouracil or capecitabine chemotherapy shows safety, immunogenicity and clinical response in patients with HER2/Neu overexpressing advanced cancer of the stomach","year":2019,"lang":"en","type":"article","venue":"Clinical Trials","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Capecitabine; Immunogenicity; Medicine; Peptide vaccine; Cisplatin; Fluorouracil; Chemotherapy; Pharmacology; Oncology; Clinical trial; Phases of clinical research; Internal medicine; Immunology; Cancer; Immune system; Antibody; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007836311,0.0004536932,0.002476539,0.00008416645,0.0001316057,0.00008803714,0.0004213347,0.000196319,0.0004723935],"category_scores_gemma":[0.002469499,0.0002115825,0.0001469658,0.0003092808,0.0003561567,0.0002551889,0.0003913877,0.0008949556,0.000003065973],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006797018,"about_ca_system_score_gemma":0.0006227786,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000617981,"about_ca_topic_score_gemma":0.001345372,"domain_scores_codex":[0.9929541,0.002307932,0.002529756,0.0009386092,0.0007891798,0.0004804189],"domain_scores_gemma":[0.9897752,0.007565108,0.001137775,0.0008099711,0.0003559126,0.0003560767],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.4471797,0.005398234,0.5261331,0.00008941641,0.0005302038,0.00004207544,0.0002100068,0.000002575086,0.0008915899,4.973871e-7,0.00003016141,0.01949248],"study_design_scores_gemma":[0.1627648,0.02707904,0.807067,0.00136997,0.0002380266,0.000009713175,0.0003191426,0.0001416881,0.0002633116,0.000002173438,0.0004825963,0.0002625869],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910799,0.0002094837,0.000003131689,0.001334376,0.00009960376,0.006942712,0.0002440319,0.00001430005,0.00007244939],"genre_scores_gemma":[0.9965166,0.0003140397,0.001046772,0.0006433013,0.0001118909,0.00009617722,0.00001939881,0.00006334222,0.001188459],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2844149,"threshold_uncertainty_score":0.8628085,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1535033077856156,"score_gpt":0.5051223840175796,"score_spread":0.351619076231964,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}