{"id":"W4248367574","doi":"10.1158/1538-7445.sabcs18-ct059","title":"Abstract CT059: A Phase Ib open label multicenter study with a HER2/neu peptide vaccine administered with cisplatin and 5-fluorouracil or capecitabine chemotherapy shows safety, immunogenicity and clinical response in patients with HER2/Neu overexpressing advanced cancer of the stomach","year":2019,"lang":"en","type":"article","venue":"Clinical Trials","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Capecitabine; Immunogenicity; Medicine; Peptide vaccine; Cisplatin; Fluorouracil; Chemotherapy; Pharmacology; Oncology; Clinical trial; Phases of clinical research; Internal medicine; Immunology; Cancer; Immune system; Antibody; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001518486,0.001623522,0.001633569,0.0004298442,0.0004502916,0.0008002497,0.0008299695,0.001108751,0.002197651],"category_scores_gemma":[0.0006846378,0.0004969638,0.001007941,0.0004155994,0.001476633,0.000891522,0.0003424769,0.00272163,0.0005822537],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008824293,"about_ca_system_score_gemma":0.00138968,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009811915,"about_ca_topic_score_gemma":0.001392285,"domain_scores_codex":[0.9994343,0.0002659295,0.00003521934,0.0001010594,0.00004827834,0.0001151962],"domain_scores_gemma":[0.9992975,0.0000838252,0.0001409876,0.00007345554,0.00004914116,0.0003549648],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.604138,0.1643465,0.007949373,0.0005468196,0.0008183262,0.0003278558,0.0003799031,0.00216556,0.1760054,0.0002067936,0.001861807,0.04125373],"study_design_scores_gemma":[0.1437665,0.834526,0.006657276,0.00001697591,0.0002218105,0.0001884486,0.00003865694,0.0006561789,0.01307522,0.00004654853,0.0007894364,0.00001692855],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979259,0.0003580556,0.0002725583,0.00009326357,0.0000473349,0.0007052012,0.0002328233,0.00003618931,0.0003286843],"genre_scores_gemma":[0.994657,0.0004650533,0.001013747,0.0002276128,0.000100991,0.001033867,0.001357258,0.00001807691,0.001126464],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002197651,"threshold_uncertainty_score":0.008030653,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1535033077856156,"score_gpt":0.5051223840175796,"score_spread":0.351619076231964,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}