{"id":"W4248474704","doi":"10.1093/nar/gnf093","title":"Tripartite molecular beacons","year":2002,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Molecular beacon; Fluorophore; Nucleic acid; DNA; Biology; Flexibility (engineering); Fluorescence; Nucleic acid thermodynamics; Combinatorial chemistry; Covalent bond; Chromophore; Computational biology; Oligonucleotide; Biochemistry; Base sequence; Chemistry; Physics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008948015,0.0005506942,0.0005372362,0.0009016693,0.0004209942,0.000728107,0.001772527,0.001572244,0.006167919],"category_scores_gemma":[0.001732068,0.000460019,0.000427773,0.0006552987,0.0004788232,0.0008107001,0.001021426,0.001368674,0.004818573],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006780603,"about_ca_system_score_gemma":0.000349314,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003168934,"about_ca_topic_score_gemma":0.0003358129,"domain_scores_codex":[0.9981073,0.0005099035,0.0001198268,0.0005130292,0.0005053472,0.0002445921],"domain_scores_gemma":[0.99909,0.0001888222,0.0001687693,0.0001307058,0.0002479827,0.0001738049],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000398552,0.00008171974,0.0003894228,0.0005899419,0.00004595534,0.0001459725,0.0001202607,0.0009352347,0.8933973,0.009241106,0.006064108,0.08859049],"study_design_scores_gemma":[0.00008331402,0.0009361216,0.0009148837,0.00006723524,0.00006086212,0.001702388,0.00006633479,0.006103063,0.8401899,0.003420889,0.1463604,0.00009459777],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.1417624,0.02571324,0.7941823,0.001962659,0.001535457,0.0010394,0.003046086,0.006114654,0.02464379],"genre_scores_gemma":[0.4790818,0.00977152,0.4664389,0.002642547,0.0002777833,0.001495126,0.006621494,0.0003763572,0.03329448],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.006167919,"threshold_uncertainty_score":0.02063376,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04368319130969557,"score_gpt":0.3524321982671834,"score_spread":0.3087490069574879,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}