{"id":"W4248487680","doi":"10.21203/rs.3.rs-18810/v2","title":"Genetic Determinants of Obesity Heterogeneity in Type II Diabetes","year":2020,"lang":"en","type":"preprint","venue":"Research Square","topic":"Nutrition, Genetics, and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"","keywords":"Insulin resistance; Obesity; Endocrinology; Internal medicine; Type 2 diabetes; GLUT4; Medicine; Diabetes mellitus; PI3K/AKT/mTOR pathway; PTEN; Insulin; IRS1; Protein kinase B; Pathogenesis; Insulin receptor; Biology; Signal transduction; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004134843,0.0002370456,0.0003675828,0.0001685124,0.0000995863,0.00002897466,0.0005502884,0.0004205838,0.00003790679],"category_scores_gemma":[0.0005045359,0.0002586251,0.00018023,0.0002152421,0.0002279994,0.000001964914,0.001956481,0.0004092405,0.00001179265],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004179395,"about_ca_system_score_gemma":0.0005170661,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001051861,"about_ca_topic_score_gemma":0.0003223334,"domain_scores_codex":[0.9974312,0.0004184327,0.0003926083,0.0007592724,0.0004793685,0.0005191389],"domain_scores_gemma":[0.9982644,0.00002749487,0.00009991293,0.0008266427,0.0005110202,0.0002705009],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002485191,0.0006036203,0.8896013,0.002340154,0.00004875028,0.0000311063,0.00008766651,0.0001277363,0.1038535,0.000003482713,0.001388163,0.001665972],"study_design_scores_gemma":[0.0006554305,0.0009756205,0.6649346,0.0003479821,0.00002005614,0.000001099447,0.000053573,0.0002977005,0.3301569,0.0009622407,0.001249751,0.000345022],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9899592,0.00876852,0.00001052739,0.00006548054,0.0001478677,0.000639162,0.0002843546,0.000009704836,0.0001151507],"genre_scores_gemma":[0.9960367,0.0028023,0.0003522288,0.00003863913,0.0003353207,0.00007326334,0.0002784585,0.00003854778,0.00004456235],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2263034,"threshold_uncertainty_score":0.9999866,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05140915435671849,"score_gpt":0.3735820389106826,"score_spread":0.3221728845539641,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}