{"id":"W4248538276","doi":"10.1158/1538-7445.am2019-2998","title":"Abstract 2998: Co-targeting bulk tumor and CSCs in clinically translatable TNBC patient-derived xenografts via combination nanotherapy","year":2019,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Research and Treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"","keywords":"Triple-negative breast cancer; Cancer research; Medicine; Wnt signaling pathway; Cancer stem cell; Breast cancer; Cancer; Paclitaxel; Carcinogenesis; Internal medicine; Chemistry; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008198521,0.0002534592,0.0002339296,0.000157729,0.00008134903,0.0001853966,0.000145478,0.0002808486,0.0009147793],"category_scores_gemma":[0.00008070724,0.00008832625,0.0001628201,0.00009727797,0.0001099953,0.0001555813,0.0001303746,0.0003352376,0.0002805901],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002453059,"about_ca_system_score_gemma":0.0001557542,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005284837,"about_ca_topic_score_gemma":0.0009276471,"domain_scores_codex":[0.9999148,0.00001023542,0.000004877805,0.00002017256,0.00003470527,0.00001522207],"domain_scores_gemma":[0.9999673,0.000005368518,0.00000852722,0.000004146618,0.000006978762,0.000007511822],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005957163,0.00004106679,0.0001020995,0.00003409385,0.000004923258,0.00003779406,0.00001109958,0.0002035713,0.9947463,0.00009240522,0.0001391523,0.004527914],"study_design_scores_gemma":[0.00002535193,0.0004632671,0.0007914719,0.000004110856,0.0000142477,0.0003369906,0.000008513791,0.002208604,0.9923345,0.00002957444,0.003778421,0.000004928113],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9827732,0.0017741,0.01134274,0.0001785615,0.00006166515,0.0001001761,0.0002873126,0.0001989974,0.00328332],"genre_scores_gemma":[0.9895189,0.000690612,0.005690886,0.00006034863,0.00001132726,0.00007696567,0.0002348867,0.0000362443,0.003679779],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009147793,"threshold_uncertainty_score":0.003060281,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03100836169755251,"score_gpt":0.388188903864401,"score_spread":0.3571805421668485,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}