{"id":"W4248570313","doi":"10.1002/ange.202001758","title":"Two Distinct Structures of Membrane‐Associated Homodimers of GTP‐ and GDP‐Bound KRAS4B Revealed by Paramagnetic Relaxation Enhancement","year":2020,"lang":"en","type":"article","venue":"Angewandte Chemie","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Canada Foundation for Innovation; Princess Margaret Cancer Foundation; Foundation for the National Institutes of Health","keywords":"KRAS; GTP'; Chemistry; GTPase; Biophysics; Membrane; Allosteric regulation; Effector; Cell biology; Biochemistry; Biology; Mutation; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009989757,0.0001282893,0.0001982557,0.00001643842,0.00004198947,0.000008739088,0.00007850366,0.00009582456,0.00005805941],"category_scores_gemma":[0.0001504214,0.0001248836,0.00005635933,0.00009694586,0.000110511,0.000004455488,0.00004861558,0.00005583624,4.784105e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009598009,"about_ca_system_score_gemma":0.00003408255,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004350485,"about_ca_topic_score_gemma":0.00001009008,"domain_scores_codex":[0.9991959,0.00003660454,0.0002617971,0.0002345518,0.000142333,0.0001287572],"domain_scores_gemma":[0.999442,0.00001432151,0.0002455817,0.0001378224,0.00008172794,0.00007851596],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008842156,0.00002629145,0.0008568996,0.0000954597,0.00005771984,6.290782e-7,0.0001117231,0.00001459691,0.9976541,0.00002783682,0.0007002748,0.0003660046],"study_design_scores_gemma":[0.0009801041,0.0001772653,0.0009444294,0.00002962811,0.00004888567,0.000001067271,0.00004126344,0.00004088396,0.9964043,0.00009505649,0.001107506,0.0001295713],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960603,0.00268195,0.0003130655,0.0001714856,0.00001929469,0.0001853439,0.00007250245,0.000007393525,0.0004887108],"genre_scores_gemma":[0.9987856,0.0001846615,0.0002920302,0.000119284,0.00003924737,0.000009511578,0.0004186073,0.00001298675,0.0001381279],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00272529,"threshold_uncertainty_score":0.5092606,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01182042685589435,"score_gpt":0.2393790197689409,"score_spread":0.2275585929130466,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}