{"id":"W4248646560","doi":"10.1055/s-0035-1554531","title":"Rationale, Design, and Early Trial Performance of AOSpine North America Multicenter Double Blind Randomized Controlled Trial of Safety and Efficacy of Riluzole in CSM (CSM—Protect Trial)","year":2015,"lang":"en","type":"article","venue":"Global Spine Journal","topic":"Cervical and Thoracic Myelopathy","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Western Hospital; University of Toronto","funders":"","keywords":"Medicine; Riluzole; Randomized controlled trial; Interim analysis; Minimal clinically important difference; Placebo; Clinical trial; Sample size determination; Adverse effect; Anesthesia; Surgery; Internal medicine; Amyotrophic lateral sclerosis; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.08258437,0.008431567,0.00717248,0.002584387,0.002852618,0.004202944,0.004034712,0.007483322,0.0259946],"category_scores_gemma":[0.05401429,0.004202052,0.003554012,0.003029907,0.006013734,0.00369339,0.001787796,0.006998674,0.007182113],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002988839,"about_ca_system_score_gemma":0.01508559,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00121806,"about_ca_topic_score_gemma":0.002535711,"domain_scores_codex":[0.9307449,0.05067587,0.003695021,0.005814834,0.006025158,0.00304434],"domain_scores_gemma":[0.9822903,0.004876156,0.003781674,0.002404677,0.003267571,0.003379513],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.827457,0.01093451,0.009970029,0.02170337,0.003897084,0.0007583427,0.0007862403,0.003150357,0.003938789,0.02538802,0.03377475,0.05824147],"study_design_scores_gemma":[0.8568743,0.04843763,0.007602112,0.004903899,0.002994376,0.0002954692,0.0002121002,0.005287811,0.001588227,0.01291942,0.0586254,0.0002593885],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.008617435,0.003922509,0.008657769,0.002577334,0.002571173,0.9667564,0.00278029,0.0001952365,0.003921804],"genre_scores_gemma":[0.01998946,0.0007068372,0.01156884,0.00236694,0.0004519904,0.9629971,0.0005755845,0.00002106945,0.001322146],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.08258437,"threshold_uncertainty_score":0.4367532,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02833030846413342,"score_gpt":0.3014435344195235,"score_spread":0.2731132259553901,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}