{"id":"W4248727854","doi":"10.21203/rs.3.rs-527648/v1","title":"Three Different Mutations in the DNA Topoisomerase 1B in Leishmania Infantum Contribute to Resistance to Antitumor Drug Topotecan","year":2021,"lang":"en","type":"preprint","venue":"Research Square","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre hospitalier de l'Université Laval; Université de Montréal; Université Laval","funders":"Natural Sciences and Engineering Research Council of Canada; Fonds de recherche du Québec – Nature et technologies; Conselho Nacional de Desenvolvimento Científico e Tecnológico","keywords":"Topoisomerase; Leishmania infantum; Topotecan; Drug resistance; Leishmania; DNA; Drug; Biology; Pharmacology; Genetics; Leishmaniasis; Computer science; Visceral leishmaniasis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000113602,0.0004380827,0.0003308156,0.0005142907,0.0001957775,0.0003954157,0.0003231156,0.0008604024,0.001698378],"category_scores_gemma":[0.0004541929,0.0002017615,0.0005578889,0.0002837272,0.000318082,0.0001099369,0.0002216253,0.0008005914,0.0003769562],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003820105,"about_ca_system_score_gemma":0.0001601914,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009963675,"about_ca_topic_score_gemma":0.0006190986,"domain_scores_codex":[0.9998469,0.00003143506,0.00001586511,0.00002552155,0.00003530088,0.00004500186],"domain_scores_gemma":[0.9998308,0.00004455845,0.00005560954,0.00001675991,0.00001834291,0.00003383795],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001191873,0.000158159,0.006627586,0.0001342537,0.00008594849,0.00208033,0.000095578,0.0006522738,0.9810172,0.0004980111,0.0003638131,0.007095016],"study_design_scores_gemma":[0.00024424,0.000775344,0.1018501,0.00007119873,0.0004088163,0.01393139,0.0003183307,0.005796763,0.8684895,0.0006163389,0.007435725,0.00006227833],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997318,0.0005303814,0.0008573525,0.0001398581,0.00002155888,0.0000181318,0.0003590647,0.00004048784,0.0007152584],"genre_scores_gemma":[0.9986095,0.0001759468,0.0003460981,0.00003820666,0.000005865235,0.000006527313,0.0003795852,0.00002005594,0.0004181777],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001698378,"threshold_uncertainty_score":0.005681634,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02982572151171447,"score_gpt":0.3508215382128085,"score_spread":0.3209958167010941,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}