{"id":"W4248928037","doi":"10.1002/ange.201510321","title":"Fast and Tight Boronate Formation for Click Bioorthogonal Conjugation","year":2016,"lang":"en","type":"article","venue":"Angewandte Chemie","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Bioorthogonal chemistry; Chemistry; Click chemistry; Boronic acid; Combinatorial chemistry; Mass spectrometry; Maleimide; Nuclear magnetic resonance spectroscopy; Thioredoxin; Chromatography; Organic chemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004475014,0.0005410456,0.0003786128,0.0002565413,0.0002162465,0.0004015541,0.0003137017,0.0005223926,0.001552806],"category_scores_gemma":[0.0003273002,0.0003418608,0.0002198184,0.0001732596,0.0003437913,0.0005700125,0.0007518557,0.000649854,0.0007751912],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000371155,"about_ca_system_score_gemma":0.0002404259,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003165947,"about_ca_topic_score_gemma":0.0005898873,"domain_scores_codex":[0.9996963,0.00004565276,0.00002560976,0.00006265276,0.00009737333,0.00007250401],"domain_scores_gemma":[0.9998696,0.00002324672,0.00002934611,0.00001812706,0.00002329596,0.00003640067],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005093115,0.00002005668,0.00004862369,0.00004009973,0.00000480548,0.00004479638,0.0000179188,0.0001657954,0.9957184,0.0008722322,0.0001248464,0.002891558],"study_design_scores_gemma":[0.00001810878,0.00009149334,0.0001393324,0.000002645156,0.000003623546,0.00006185214,0.000004795947,0.0008842816,0.9969859,0.0001054585,0.001693149,0.0000095253],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8840891,0.001852319,0.1082052,0.0002750161,0.0001362904,0.000220913,0.0003761397,0.000760288,0.004084894],"genre_scores_gemma":[0.9709004,0.0006631496,0.02519117,0.00009190405,0.00002071466,0.00008277903,0.0002952764,0.00006989518,0.002684628],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001552806,"threshold_uncertainty_score":0.005194724,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02033248259616352,"score_gpt":0.2512109587809153,"score_spread":0.2308784761847518,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}