{"id":"W4248928037","doi":"10.1002/ange.201510321","title":"Fast and Tight Boronate Formation for Click Bioorthogonal Conjugation","year":2016,"lang":"en","type":"article","venue":"Angewandte Chemie","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Bioorthogonal chemistry; Chemistry; Click chemistry; Boronic acid; Combinatorial chemistry; Mass spectrometry; Maleimide; Nuclear magnetic resonance spectroscopy; Thioredoxin; Chromatography; Organic chemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006474013,0.0001272588,0.0001121765,0.00001408889,0.0001238853,0.00002614328,0.00008911647,0.0001130137,0.0003751514],"category_scores_gemma":[0.00004780092,0.00009782962,0.00005530708,0.00004526022,0.00007464709,0.0001850515,0.00003192818,0.00004705793,0.00001941784],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004423225,"about_ca_system_score_gemma":0.00001757556,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002233404,"about_ca_topic_score_gemma":0.000004403079,"domain_scores_codex":[0.9993036,0.000001877067,0.0001999181,0.0002309685,0.00007789834,0.000185729],"domain_scores_gemma":[0.9994217,0.0001232501,0.0001034431,0.0001946994,0.00007118407,0.00008577648],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002523285,0.00002373405,0.0004880821,0.00009764022,0.0000132038,2.058791e-7,0.00005272922,1.275931e-7,0.9858309,0.0006652332,0.003049517,0.009753371],"study_design_scores_gemma":[0.0007780222,0.000005952367,0.0001206063,0.00004676502,0.00002043744,0.00001033638,0.00003620819,0.00001746012,0.8785052,0.001118144,0.1192001,0.0001407445],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.967204,0.0002062825,0.00300477,0.002955445,0.00003113932,0.0001618691,0.0005338562,0.0001491895,0.02575342],"genre_scores_gemma":[0.9939489,0.0001306705,0.0003789604,0.0001041509,0.0002533849,0.0001791818,0.0003209578,0.00001680058,0.004666999],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1161506,"threshold_uncertainty_score":0.4107644,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02033248259616352,"score_gpt":0.2512109587809153,"score_spread":0.2308784761847518,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}