{"id":"W4248939802","doi":"10.1002/anie.201713428","title":"Competitive Affinity Release for Long‐Term Delivery of Antibodies from Hydrogels","year":2018,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Foundation for Innovation; McMaster University","keywords":"Conjugate; Chemistry; Streptavidin; Self-healing hydrogels; Antibody; Biotin; Agarose; Controlled release; Drug delivery; Combinatorial chemistry; Chromatography; Biochemistry; Pharmacology; Immunology; Polymer chemistry; Biology; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002320043,0.0003022455,0.0001203702,0.00009772817,0.00009994966,0.0002670232,0.0002072915,0.0002599479,0.000938492],"category_scores_gemma":[0.0002331021,0.0001355093,0.0001643979,0.00006919345,0.0001294778,0.0002384432,0.0001772932,0.000398363,0.0003873754],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004561041,"about_ca_system_score_gemma":0.0002199437,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004436357,"about_ca_topic_score_gemma":0.0008350482,"domain_scores_codex":[0.9998782,0.00001645651,0.00001060673,0.00002967071,0.00003946988,0.00002564067],"domain_scores_gemma":[0.9998538,0.00004439401,0.0000497186,0.00001222966,0.00002150904,0.00001837679],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001925293,0.000007689376,0.00003146997,0.00003409829,0.000002369264,0.000015964,0.000008702202,0.00006645223,0.9973629,0.000119121,0.00005407317,0.0022779],"study_design_scores_gemma":[0.000005893076,0.00009049305,0.0002431121,0.000003636652,0.000004993777,0.0000728981,0.000003304865,0.0008530345,0.996864,0.00002205096,0.001832692,0.000003901108],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8963993,0.01068691,0.08710815,0.000352696,0.0001406222,0.0001046784,0.0002202175,0.0002977751,0.00468965],"genre_scores_gemma":[0.9817966,0.001539922,0.01311041,0.0001008824,0.00001709106,0.00005407732,0.00008771213,0.00003100918,0.003262221],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000938492,"threshold_uncertainty_score":0.003309309,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03396006319066538,"score_gpt":0.3277103972847434,"score_spread":0.293750334094078,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}