{"id":"W4248977310","doi":"10.1158/1538-7445.am2019-3461","title":"Abstract 3461: Characterizing the PTEN - p85alpha interaction","year":2019,"lang":"en","type":"article","venue":"Cancer Research","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Saskatchewan Cancer Agency; University of Saskatchewan","funders":"","keywords":"PTEN; Docking (animal); PI3K/AKT/mTOR pathway; Phosphatase; C2 domain; Binding site; Computational biology; Phosphatidylinositol; Protein kinase domain; Chemistry; Cell biology; Kinase; Cancer research; Biology; Biochemistry; Phosphorylation; Signal transduction; Gene; Mutant; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001561087,0.0003934668,0.0002162884,0.0002898821,0.0003062051,0.0002158031,0.0004350073,0.0003032954,0.003190899],"category_scores_gemma":[0.0002203121,0.0001485144,0.0003055196,0.0003877472,0.0001247617,0.0001819054,0.0002229918,0.0003879374,0.0008819707],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003748476,"about_ca_system_score_gemma":0.0001629582,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001305139,"about_ca_topic_score_gemma":0.001015096,"domain_scores_codex":[0.9998455,0.00001377986,0.000007992056,0.00002909,0.00007229264,0.00003121937],"domain_scores_gemma":[0.99994,0.00001472613,0.00001349543,0.000005208268,0.0000120708,0.00001448944],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003053434,0.0001062121,0.001757572,0.00006824564,0.00002182666,0.0002645013,0.00002879672,0.002828876,0.9911633,0.0003761573,0.00024253,0.002836719],"study_design_scores_gemma":[0.00005275307,0.0004227954,0.0148027,0.0000116752,0.00004713586,0.0005853486,0.00005801937,0.05487039,0.925804,0.0003045275,0.003026709,0.00001403021],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925308,0.0002304659,0.005236048,0.00004558699,0.000009787221,0.00002633425,0.0004848817,0.00007478508,0.001361269],"genre_scores_gemma":[0.9915949,0.0001961993,0.00451262,0.0000220615,0.000003117988,0.00002217012,0.002018192,0.0000199121,0.001610888],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003190899,"threshold_uncertainty_score":0.01067466,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07128664663999323,"score_gpt":0.4145289401213658,"score_spread":0.3432422934813726,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}